Paclitaxel Desensitized

Hi all, I would like to ask if anyone has had an allergic reaction to Paclitaxel and if you were offered a desensitized version to enable your body to tolerate it. Also do you know what they do to desensitize it, (Pharmacist can tweak it and desensitize) just curious that's all. I had three reactions and on the third I was tried having the IV infusion slower over four hours and alongside saline solution to dilute but I still reacted. X

  • Hi

    I can't help with your questions but I noticed that you hadn't had any replies yet. 

    I can see that you're a member of the womb cancer group and hope you don't mind me suggesting that you also post these questions there as it's a much more active group than this one and you'll probably get a reply there.

    You could also post your question about desensitizing in the ask a nurse section of the online community and one of the specialist nurses will aim to reply within 3 working days.


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  • Hi Mad. I asked my Oncologist about the desensitized version yesterday. He's not a chemist but did say they do tweak it somehow but as a result it's more costly to make whereas the normal Paclitaxel probably comes in huge vats. As a result of the increased cost it might not be offered to all patients as a matter of course. (Probably not oldies like me!)

    I asked, not because of an allergic reaction to the drug but because of my Peripheral Neuropathy which he can't tell me for sure if it will go. He did say he can increase my dosage of Gabapentin which may help. He also said if I have symptoms after 18 months its unlikely to go. I can still walk 5 miles daily but do admit, when I get out of bed in the morning, I walk like a penguin for a while!

    Hugs, B xx

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  • Hey Barb I'm so happy today's appointment was positive news for you, how on earth you held it together beforehand I do not know, relax now, have an aperol spritz to celebrate and cheers! 

    TadaConfetti ballTadaConfetti ballTadaConfetti ballTada 

    Im glad you asked about the alternative Paclitaxel, Hopefully you won't need it, my understanding is the Pharmacist can tweak it in the pharmacy and shouldn't cost much more than the original. The expensive version is called ABRAXANE, this I'm told is not funded by the NHS.

    Take care xx