Immunotherapy adverse event

1 minute read time.

I have now had 3 doses of pembrolizumab and 9 of NAB-Paclitaxel. We went away for the weekend and had a number of treats, including spending Sunday afternoon at the London athletics event. We weren’t directly in the sun, I was fairly well covered, and had SPF 50 on exposed parts, so I was a bit surprised when I had what looked like sunburn across the top of my chest. I moisturised it, took an anti-histamine, and didn’t think much more of ir. It seemed to settle down on Monday and Tuesday. 

Wednesday was treatment day, just chemo this week. By the evening, I noticed the area around my port was a bit red. By the next day I was back to the sunburn effect across the neck and upper chest area, despite not having had fresh exposure. The day after that (today) I woke up to find the rash had spread down over both boobs, and there were also patches on my abdomen and pelvis. 

A quick call to the acute oncology helpline led to me being admitted to their assessment ward. It would appear to be an adverse immunotherapy event, where my immune system is attacking my skin. Fortunately at this stage it’s still a grade 1 event so I was sent home with various potions and tablets, and am currently still scheduled for my 4th dose of pembrolizumab next week. 

My first (post starting this treatment) round of CT and MRI scans are in the diary. Obviously hoping it’s doing its thing whilst hoping I don’t have more issues with adverse effects. Cancer markers are stable. 

Anonymous
  • What a journey you've had, dear Codfish! You are an inspiration! I wish you the very best of luck and keep fighting! I find staying positive so hard at times but I know I will keep fighting too. Lots of love, xx 

  • Wow, its quite a journey. I really hope you can continue on with the immunotherapy as it sounds like it hits the spot for your cancer. Are there any trials for triple neg that you are eligible for or anything up and coming? Have you asked Patricia Peat about whats going on and where? SHe seems to have a good handle on whats going on outside the UK if that is ever of interest. Hoep your skin settles down and that you are not uncomfortable with it.

  • Hi Zephyr. I do keep a look at trials. ModIfy might be relevant when it reaches the next stage (it’s currently very low volume safety trial stage) as it’s testing a targeted injection in conjunction with PD-1 inhibitors. I don’t think it will reach mass comparison trials soon enough for me as I am limited to 2 years on pembrolizumab (if it works for me). There are possibly some other TROP2 inhibitors in trial (my next line of treatment, if this doesn’t work would be one of them). I would be cautious about entering a trial that wasn’t fairly local as travel is a pretty heavy load when you are already having treatment. 

  • Sorry to hear that you had an adverse effect due to immunotherapy. Hope it clears up soon and that it doesn't happen again.

    Best of luck with your CT and MRI scans. xx

  • Thank you Daisy. It’s settling down well.