Stomach cancer stage 4 Folfox Nivolumab

Hi SIVSCFN, 

First I’m very sorry for your mother’s diagnosis. This is such hard news to deal with. FOLFOX is an incredibly strong chemotherapy combination and is a proven treatment method for stomach cancer. And Nivolumab is a great first line immunotherapy option for stomach cancer - did your mother get bio marker testing done? If the malignancy has high PD-1 levels, the Nivolumab could be incredibly effective. 

Are you in a country where stomach cancer is more prevalent (typically eastern Asian countries)? If so, her doctors will be better equipped even for advanced cases. Even if you’re not, FOLFOX and Nivolumab is a great start.

Support her best you can even though I am sure you’re feeling scared and distraught. It took me about a month to come out of the fog of despair. My mother was diagnosed with stage 4 stomach cancer in November and while I’m still incredibly sad, upset and scared, I’m not as paralyzed by those feelings as the first few weeks. 

While stomach cancer is a more rare cancer in some parts of the world, there is great research being made. 

Sending you love and positive energy,

Jessica 

Hi Jessica,

It has the PDL1 variable at 8. And according to the trial, Nivolumab can be given with values ​​greater than 5.

We live in Spain.

We were also diagnosed in November. I hope everything goes well with your mother and good luck.

What treatment are they going to give your mother?

A hug and we keep in touch, 

Elisabeth

Hi Elisabeth, 

That high PD-1 score gives me a lot of hope that the immunotherapy will be successful for you mother. 

My mother’s tumor is HER2 negative and does not hit the threshold for PD-1 so she’s currently on 5FU, docetaxel and oxaliplatin. Her tumor was found to be through the serosa layer during the laparoscopy and her team staged her case to stage 4 at that point. She will be completing her 6th round of chemo this month and hopefully will be getting a partial gastrectomy plus HIPEC if the cancer hasn’t spread. Then two more rounds. We’re thankful that her team is treating her aggressively to give her the best chance. 

I very much would like to keep in touch as well. 

wishing you well,

Jessica 

I was diagnosed last July with stage 4 stomach cancer with nodules on my peritoneum and enlarged lymph nodes between my lungs it is inoperable and not curable but can hopefully be controlled for now. I was started on oxaliplatin  and also was a candidate  for nivalumab. After 4 courses of infusions and after a scan which showed the cancers had responded they stopped  the oxaliplatin and I have been having 4 weekly treatments with nivalumab immunotherapy have my next dose this week.and then a CT scan later this month , hopefully it will show improvement or at the least no change .. the only side effects i have at the is very bad fatigue and tiredness , but that could be down to the chemo ..

Hello,

Thank you for telling me your experience.

My mother has two sessions of Folfox chemotherapy every two weeks.

If it gets a little stronger, they will start with Nivolumab + chemotherapy in the other sessions every two weeks.

Since my mother has a lot of fatigue and tiredness before starting the treatment. It will be from the disease itself...

I hope everything goes well in your next checkup. We keep in touch.

Elisabeth

Hi,

The tumor markers are at CA 19.9 15000 and CEA 100.
Have any of you had them that high??

Greetings

Hi

I am so sorry for your mother’s diagnosis.

I know what you are going through as I am currently caring for my husband who has stage 4 stomach cancer.

He just completed his first line of treatment ; 6 doses of CAPOX and one dose of immunotherapy. He has a break of 2 months before he is reviewed again.

We have been looking into HIPEC but our hospital is not aware of it. They are willing to support us if we were to find one.

If you are based in the UK , would you mind sharing the details of your mother’s hospital/ medical team?

Wishing you all the best!

Thank you so much…

Hi

How did you see that the tumor responded?

My mother's tumor markers have gone up a lot in the first two cycles of chemotherapy.

Is it normal? Or is she not responding to treatment?

Thank you

Before chemo i used to get niggly stabbing pains in my abdomen, however these diminished even the discomfort around my stomach was less..however a CT scan did show that the cancer and the peroteneal  nodules had reduced in size apart from a couple of lymph nodes between my lungs which did show slight growth ..

Thanks for your response Ukmartian.

Do they control the CEA and Ca 19.9 Tumor Markers or do they only look at you with CT scan?

I am worried because the tumor markers have risen a lot and it may be that the tumor has advanced...

I hope someone can tell me their experience with tumor markers.

Thank you