Quick brief on the situation:
BW initial PSA 115, full pelvic RT, Zoladex and Abiraterone for three years. Now taking a break from meds. Last Zoladex mid December-. so HT leaving his body around end of March this year. Last blood test 6 months ago.
He started his HT early so scans didn’t show any Metastatic spread, though two consultants said highly probable and masked by HT.
This blood test is showing PSA exactly the same, but the Liver function is showing serum Alkaline Phosphatase ( ALP) has shot up by 133 points. To 178. Obviously to me (over thinker) this is saying it’s in BW’s bones and it’s now starting to show itself since HT has stopped, maybe? Hopefully I’m over thinking . He’s taken Calcium, vitamin D, magnesium and vit C through this whole experience, so it’s not a lack of those.
We’ve long accepted that this is what it is and we’ve been prepared for it, even though there’s been no real evidence, just statistics.
So, what I’m after is any information you have in ALP scores and metastatic spread? From the T4’s please or has anyone ever had a big ALP jump with it going down again and not being anything bad, just a blip.
He’s booked in for another blood test in two weeks to double check it. Also it feels very mysterious that the PSA is the same as last time.
L
My PSA doubled to 738 & the ALP doubled too.
Hello, I'm a T4 with wide metastatic spread including bone mets. I've been on HT for getting on 3 years since diagnosis.
To answer your question, whilst my PSA has steadily declined from 90 at diagnosis to currently less than 0.5, my serum ALP has had a couple of bumps. The overall trend has been for it to lower - from 227 to 80 - but I've had two unexplained jumps that haven't followed a rise in PSA. I guess what I'm saying is that in my case, the ALP increase didn't mean cancer activity in the bones.
Hope this helps? 
