Olaparib

Hi Stem

I do remember reading about this drug some time ago.

Think was launched about 3 or 4 years ago.

Apparently exploits a weakness in cancer cells without harming healthy tissue, good for advanced cancer.

Hopefully someone might post who has tried it but it does sound ok.

Try searching on the web , must be loads of info there

Best wishes

Steve 

Hello Stem, I have just looked up Olaparid on the Prostate cancer Uk website

www.prostatecancer.org  They give a really good explanation of how it works, when it’s used and what the side effects are. 

I really hope it works for your husband !

Hi Stem.   I am PCa stage 4, mets in bones.  Diagnosed in 2014.  I tested positive for the BRCA2 gene mutation present only in cancerous cells (not inherited).  I have been on Lynparza for 14 months. 

First comment is it is not targeted.  The parp inhibitors seek out both cancerous and non-cancerous cells.. hence there are side effects.  

As for the dosage.. I began on 600mg/day, was too much and reduced to 400 after 3 months, which I stayed on.  

For me the main SE was constant fatigue.  But it also distorts taste, upsets digestive system.   It is important to stay active: I go to the gym regularly for cardio and weight bearing exercise; also play golf.  

That all said, it has kept the cancer at bay: no radiographic progression, and blood counts ok albeit red and white cells a bit low. 

I am on a 4week treatment holiday right now, and generally feeling better.  Will do blood counts and see oncologist early September.  

I hope this info is useful.  Let me know if I can help further.