Seminal vesicle Amyloidosis (SVA)

Hi AW

Amyloid in the vesicle, from what I've read this isn't part of the PC but could be wrong there.

I presume at the moment cancer contained?

What treatment are they suggesting

Steve 

Hi Steve,

yes, not in the prostate gland itself, but found on biopsy in the seminal vesicle (I only have a 25cc prostate gland, so I guess the needle got all the way into the “ears”).

it looks like PCa is contained, but they want to check for any possible spread before recommending either surgery or HT/RT

Yes good idea because if even just outside the gland probably better off with RT.

Looks like your PSA not high so doubt if spread.

Steve 

Yes - I’ve been watching a series of videos from Dr Sholtz (PCRI) and I’m certainly interested in combination RT with Brachy, with a side of HT

You are indeed correct that it is not associated with prostate cancer - however, it is found in about 10% of prostate biopsies, during pathology post surgery. Always found in the seminal vesicles (not the gland) and very different from the dangerous systemic amyloids. Thought to be local, but I guess there is still some doubt so the good old NHS will pay for a CT scan to check that it hasn’t converted to systemic. 
as I have cribriform (a pattern type on grade 4, found in around 40% of samples), this also has to be checked it hasn’t gone walkabout (as Millibob would say), as it’s often found in distant mets. I just hope we’ve caught it in time 

Yes only read about cribriform a few days ago, still trying to work that one out 

Best wishes

Steve 

Steve - You are not the only one. There's not to much written about it but from what I understand it makes the spread quicker and requires more urgent treatment.

Let's hope 

Alpine Wanderer said:

it hasn’t gone walkabout (as Millibob would say),

I hope we have some Community members who know something about this as I would like to broaden my knowledge in this case.

And Alpine Wanderer . Yes I do hope it's contained. Keep us posted.

Best Wishes

Brian.

Yes, thanks Brian.

Have tried reading about it online but haven't got very far ,  am sure you're right,  easier to spread 

Best wishes

Steve 

Hi Millibob,

just to clarify things, the cribriform is a cell pattern rather like a “basket weave” (hence the Latin term crib) and was present in my Grade 4 samples. In my research I found that cribriform is found in up to 40% of all patients’ grade 4 PCa - that’s why we all have to have treatment to remove or kill it whilst it is still local.  

Good explanation