Letrozole - how effective is it?

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Hi All, this is my first time posting. I’d like to know how effective letrozole is for stopping ovarian cancer from coming back. I’ve only been on it 2 weeks and it’s like I’ve had a personality transplant. I am usually a very calm person very slow to anger, and happy (even when going through treatment). This last 2 weeks, ive been getting progressively worse - crying constantly, quick to anger, sad, anxious. The brain fog is ridiculous; I cut my finger with knife, nearly crashed my car, forget what I’m saying mid sentence. Pain and swelling in my hands and joints. - just for reference - I’ve been through or was going through menopause when we found the cancer so I’m no novice to those symptoms but this is so much worse.

So back to my question- How effective is it? Do these symptoms reduce as your body gets used to the drug?

  • Hi D4wn

    Welcome to the Ovarian cancer group. 

    I am sorry that you have not yet had a response to your post but sometimes it can just take a little longer for someone in similar circumstances to see it and offer support. 

    My own cancer was endometrial but there can be similarities in treatments. 

    I am sorry that you are having such severe effects from your letrozole. Have you spoken to anyone about this? Your CNS/doctor? It may be an idea to speak to someone to find out whether these effects are to be expected and whether they are likely to resolve with time. Sometimes if one type of medication does not suit you and alternative may be available. With effectiveness that maybe something to talk through with your CNS/doctor as they would know your original diagnosis and things like grades/stages/molecular factors may be important. 

    If it would help, please do give the Support Line a call and talk to one of the nurses. They would be able to talk to you about letrozole and give more details. 

    In the meantime I will pop a link below with some info that may help.

    Letrozole | Macmillan Cancer Support

    Jane

           

    Macmillan Support Line - 0808 808 00 00, 7 days a week between 8am-8pm

  • Hi Jane, thank you. Yes, I’ve contacted the Nurses and they are going to look into it for me. Thank you for the advice.