Immunotherapy treatment

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My husband was diagnosed with metastatic melanoma in December 2024.we were told there was no cure but he was offered ipi/nivo immunotherapy treatment for 2 years. He has just completed treatment 4 of ipi/nivo and will now start nivo only. He has had a few side effects ,slight rash treated with steroid cream, a few temperatures of 30+ that go with paracetamol. He is now suffering from extremely cold white hands which I have read is also a side effects. Has anyone else suffered this one. I am now getting extremely stressed knowing that the first comparison scan will be coming up soon, can’t stop thinking about it. would love to hear about any positive results people have received. forgot to mention hubby’s cancer is stage 4 .