Dabrafenib and Trametinib

I was on them from Jan 2025 to Feb 2026. Generally didn't have too many bad reactions. Tiredness/Fatigue would come and go. I had small infections in the fat layers which lasted anywhere from 24hrs to 2 weeks which could feel like a bruise, some more painful than others but more annoying than anything else. I craved really sweet things like chocolate even enjoying white chocolate. As soon as I stopped the treatment, the sweet cravings went away.

The only really bad reaction I had was a mild general infection which sent my body into an auto immune response with a very high temperature which I had to have intravenous antiboditcs for and had to stop the medication for a couple of weeks. 

I certainly feel that the treatment regime was far less invassive than chemo, radio or even immunology. I stayed completely off alcohol and just tried to rest when I was very tired. I tried to work from home as much as possible, which meant that if I need a quick nap in the day I could just get 20/30 min on the sofa. 

Wishing your husband all the best with his treatment.

Thankyou for taking the time to reply I will pass this on to my husband. 

Hi I was on them from November 2023 to end of march 2024 unfortunately I only done 4 months due to side affects and finding thyroid cancer which was successfully treated with surgery. I had side affects about 6 weeks after starting which were high temperature, cough and rash spots o  face and back, I had them paused a couple of weeks then restarted again after 6 weeks I had cough high temperature and liver blood test went to grade 3 toxins. Not everyone gets side affects. I'm still no evidence of disease. I have check ups and scans now. Hope it goes OK for you.

Other than a very slight rash I had no side effects and did the full 12 months in 2019. 

Hi I have been on Debrafanib and Tramatinib since May 2024. It took approximately 8weeks adjusting after having bone infusion i started getting high fevers and many overnight stays in hospital on antibiotics and i had to stop for few days. Eventually I restarted them after a course of 3 day antibiotics combined with a small dose of steroids prednisone. I am enjoying most foods high protein but foods with long shelf life tastes bitter. Now all seems fine so far. I consider myself very fortunate to get this only treatment available for the type anaplastic thyroid cancer treatment with Braf marker. I hope this helps. Good luck!

Hi, about half way through my 12 months. With the understanding that everyone will have different symptoms and side effects - I have minor GI issues and a little more tired. However I still cycle to work and do a couple of jogs a week (shorter than before). I hope your husband is doing well with minimal side effects.