First Treatment of partner - Nivolumab and ipilimumab side effects?

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My partner had their first treatment last week of Nivolumab and ipilimumab, and wondered how others found that it affected them?  Did it take long for the side effects to kick in and were there any 'lucky' people who did not get any at all after the first session?

They are finding it very hard to sleep at night so wondered is this a side effect of the drugs or just the entire situation we find ourselves in. 

any help greatly appreciated.