Keytruda/Zometa & joint pain

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Has anyone suffered severe knee pain after keytruda or zometa?

My husband had his 4th keytruda & 3rd zometa nearly 2 wks ago & since Tuesday his knee pain is flooring him. Previously to his cancer diagnosis he had arthritis in knees & had several knee procedures years ago.

His knees havent been this bad in years, also ankke swelling which as been ongoing for months, which nobody can find out whats causing it.

He normally as a few bad days after treatment & joint pains, but never as bad as this. 

Hes taking cocodamol & oramorph but it isnt really helping the pain, as I think he needs anti infamotories, which he cant take due to having a stroke.

Just wondering if anyone else as suffered these side effects?

Thanks.