Hello,
Posting on behalf of a family member. Diagnosed with RCC in summer, had a radical nephrectomy and on adjuvant immunotherapy - taking Pembrozulimab.
Started on immunotherapy in September, at this time kidney function (eGRF) was around 58, quite a big improvement from post-surgery. About four weeks after the first cycle of treatment this number fell to 40 and creatinine was about 156.
Really concerned as have been trying to speak to someone about this but no one seems concerned even though it feels like a significant decline? Spoke to a doctor late on Friday who said it isn't ideal but would be monitored and wouldn't be a reason to pause treatment.
But given the fact this huge drop has come after one cycle of Pembro very concerned about the next one which is due to take place later this week.
Has anyone been in a similar situation re kidney function dropping this much because of Pembro? Really keen to know if it's a temporary side effect. And trying to work out if I should be going ahead with the second cycle this week or not?
Thank you.
