Clinical Trial - Modi-1 in Renal Cancer (The ModiFY study)

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Hi Folks

This trial is currently underway and will be opening again for more candidates in some locations in due course. I've been provided the info as I tick the boxes.

The purpose of the study is to find out if new treatment Modi-1 can be used safely for breast, H&N, ovarian or renal cancer and benefit these types of cancer. Modi-1 is designed to help your immune system attack and destroy cancer cells.

Brief Summary: "The main objectives of this study are to assess the safety, tolerability, immunological activity, and preliminary efficacy of the Modi-1/Modi-1v vaccine, both as monotherapy and in combination with a checkpoint inhibitor (CPI) such as pembrolizumab or nivolumab (where these are standard of care in a non-neoadjuvant setting), in patients with advanced triple negative breast cancer (TNBC), advanced/unresectable human papillomavirus-negative squamous cell carcinoma of the head and neck (SCCHN), high grade serous ovarian carcinoma (HGSOC), or renal cell carcinoma (RCC)."

Just sharing as a heads-up, to meet others considering it, or on it. I haven't done the background reading yet but I'm likely to go for it.

Mmum over 2 years ago

I just started on the trial this week (june 2023). ModiFY Trial Day 1 My arm is a right mess!.

Rojan over 2 years ago in reply to Mmum

Sounds nasty! Is it something that may withdraw you from the trial or an expected treatable side effect?

Mmum over 2 years ago in reply to Rojan

Expected treatment side effect! The injection sites (4 of them) inflamed like a wasp sting, then the whole area went red and swollen, then the skin broke on one and weeped. So one has a big scab another just looks infected although it's not yellow enough for that.

It's a mess in a good way! And I read that everyone on the trial got a reaction at the injection sites and it's indicative of the modi-1 reacting with the immune cells.

I think I didn't believe them when they described it to me because we all have vaccines all the time and don't experience this. Also I've never had any side effect that I've been pre-warned about. I get the rare side effects in the small print!

Hampton over 2 years ago in reply to Mmum

I would put up with the red and swollen arm if it was a sign the treatment was working. At least you can feel positive things are happening which is better than not knowing and the anxiety that goes with it

The skin reaction you have sounds like the symptoms I suffer with mosquito bites. It’s very unpleasant but your arm will recover in time.
If the consultant says it’s a good sign then the future is looking good for you.
Thanks for keeping us posted about your journey

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Clinical Trial - Modi-1 in Renal Cancer (The ModiFY study)