Dad with head and neck cancer

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Hi there,

My dad was diagnosed with a head and neck cancer (HPV+) with an unknown primary four years ago. He had a radical neck dissection two years ago and it has now come back. He had a surgery to remove a cancerous lymph node a few months ago and now needs to do radiation. 

1. Does anyone have experience with not being able to find the primary? 

2. How should we prep for treatment? He is having radiation to his whole neck and I want to be prepared. 

Thank you!

S