DLBCL High Dose Intravenous Methotrexate (Intravenous)

Hi Hil, I never had Methotrexate so let’s see if some of the others can help........ but I would think that as it is designed to protect the CNS it may well other areas, but I am no expert.

Hi Mike,

Thank you. He's had the 3 intrathecal rounds but the next two are a drip hence why I was wondering. Additionally because he's had partial response and only has one more cycle of r-chop so if the methotrexate doesn't help with the cancer then I'm not sure why they've said the final PET scan won't be until after these two additional treatments. 

Hil

My treatment was strong and slow so a treatment cycle lasted 120 hours every three weeks for 6 cycles. 

I remember we my SCN say “even once you finish all your chemo it will keep working for months after so no point in doing a scan immediately after the end of treatment...... we have to give it time”

Easy for me to say, but try and not overthink things and if you have questions go ask his team as they are the experts and can give you a clear understanding as to where his treatment is at - every journey is unique ((hugs))

This is similar to my treatment plan.  I will have 4 intrathecal doses of methotrexate during R-CHOP and then two consolidatiion doses of methotrexate and rituximab when R-CHOP is finished.

The difference in ROA is that the intrathecal doses are intended to prevent lymphoma to spreading to my CNS (I had a mass in my sinus cavity), while the systemic doses are intended to knock out remaining lymphoma cells in the rest of the body.

I'm on R-CHOP 14 so I will  have no imaging done during my treatment.  

Hi Lolie,

Thank you for taking the time to reply. 

Dad had 3 x intrathecal as one area of his was close to his spine.

I don't know if Dad is having the extra Rituximab but your feeling is the high dose methorexate can also work to kill the cancer as well? 

Thanks,