I was diagnosed with CML in Jan 2021. On Imatinib for a year (changed due to side effects). Then Dasatinib for 3 years. Stopped due to huge plural effusions on both lungs found after a few months of being unwell, cough, losing weight and shortness of breath. After lung aspirations and a lung biopsy they thought initially it may have low grade B-Cell lymphoma but then decided it was caused by the Dasatinib. Therefore, cannot go back onto Dasatinib. Been off treatment now for 7 weeks.
About to start Asciminib in the next couple of weeks. Any insight into what to expect as side effects or in general would be appreciated. Also further treatments after Asciminib should this not be tolerable also.
My bloods and BCR/ABL have all been good whilst on Dasatinib.
Thank in advance.
Hi Tina 
I have had CML since February last year and since then I have been on Imatinib, Bosutinib and now Asciminib.
Imatinib made my white blood cells go too low and the Bosutinib badly affected my liver. I have been on Asciminib since September and all my bloods have been fairly stable. As far as side effects go I have had a skin rash on my neck, very mild, not particularly nice looking but not irritating. My liver levels aren't perfect but they aren't enough to stop the medication.
It's really hard to know how we will react to these medications but the only way to know is so start taking them!
I hope that helps a bit! A x
Hi
Thank you for replying. Yes I agree, the only way to tell is by starting the drug. I have an appointment Monday to consent and pick up my medication after 8 weeks off Dasatinib so will see how I go. Expecting a few hiccups along the way 
but as long as it keeps my numbers good without to may unmanageable side effects that will be good.
Hope you continue to do well.
Tina
