Triple neg but low ER and HER2

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Hi all, 

Wondered if anyone else had had this? Im halfway through the keynote regimen for triple negative with lymph node involvement. A few weeks into chemo i got my full biopsy results from the surgeon, which had the tumour down as ER4, and HER2 2(fish negative).

Have yet to meet with oncologist since initial appointment so will ask her for more info, but has anyone else had this? I thought TNBC was a binary thing, but could i also have very low expression of estrogen receptors and/or HER2? If so, would having additional hormone blockers or herceptin make any difference here? 

Thanks for any insight!

  • Hi  

    As far as I know TNBC means no receptors for oestrogen, progesterone and HER2 although I have heard of people before also having low levels of HER2 (fish negative) as being classed as having tnbc. I guess it would be interesting to know whether the low levels of oestrogen and HER2 receptors from your surgery pathology are new news, or were known at biopsy. Your oncologist is the only person who can advise whether it changes your treatment plan. 

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