Hi
Abemaciclib - i started on this Mid April 2026 and dose reduced to 100mg 5 weeks ago.
Diarrhoea is the main issue, 2-3 times per day. Told to take Imodium {Lopermide} 2.5mg at first loose motion.
my concern is taking Loperamide over 2 years what impact will it have on the bowels.
or is this something we just have to go with.
I had lumpectomy, Grade 3, hormone fed cancer and 4 cancerous lymphnodes, chemo, radiotherapy and Letrozole.
any thoughts
thank you
Hi,
you seem to be on the same path as me, in my case Grade 3 with 2 affected lymph nodes. I finished the abema in early May this year.
I got the diarrhoea for the first 6/8 weeks plus occasional excruciating abdominal pain, but really didn’t want to use loperamide I made my diet really bland and that helped a lot. It was a bit tedious, but preferable to the excitement of sudden outpourings and rushing to the loo. I was able to go back to my more normal way of eating with more roughage and veg raw or with some bite left in them. I just sensed gradually that I was ok to do that.
i had a phase of feeling that I would get through just fine but I did have some bad coughs in the first winter and various other infections at other times, but not too bad overall. Tiredness became a thing in the last 6 months or so and I have been glad to finish.
All the best with the pills, it’s not a great experience, but I believed it to be a valuable prescription for me to take. xxx
p
Hi there, I am currently taking 150mg and the stomach issues have settled down quite a bit - I am now on my 4th cycle. I have found it worse if I eat too much fat, ready meal style meals- such as a pizza with salad and coleslaw ! But generally if I cook food myself and keep off very rich sauces it seems better. It’s not nice and hope yours settles down too ! The tiredness is sometimes horrid and then I get a bout of good days. I find I worry about infections etc and hope in time I can relax a little more.
thank you, wish you well with your tiredness and anxiety.
good to know i am not the only one with these issues
you have done well and got through it, my best wishes
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