Zarzio/filgrastim side effects

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Hello to all.

I'm currently on cycle 2 EC-T Chemotherapy, and taking Zarzio injections from day 5 to 10. I have found, now that yes, the EC chemo is giving me the usual unpleasant but controllable symptoms in the first few days after infusion, and then I start to feel better. But when I start Zarzio injections on day 5, I seem to have a really bad reaction to them. Apart from the indicated side effects of bone pain, muscle pain, low energy, headache, sickness and weakness, I have had bad stomach aches, a kind of debilitating nervy pain shooting up my spine, vertigo, breathlessness and am basically just able to get out of bed and go to the loo. On the morning after my first injection, I ventured down to the kitchen to make a cup of tea, and collapsed. I have been in bed for 6 days with this, now two days after my last injection and beginning to feel a little stronger. I called the red number three days ago and the doc said that yes, it can make people feel poorly. Is my reaction normal? I just feel that this is a bit more than 'poorly'! Has anyone had this type of reaction to Zarzio? If so, what did you do?

Many thanks in advance

  • Hi I noticed your post had dropped down as the site is busy and some folks may have missed it.  I can't help you myself, but this reply will bump it back up so I hope someone with the right experience will be along soon.  I hope your side effects ease soon

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  • Hi jasa, yes I had terrible shooting pains from pelvic/ abdominal area… punching or pulsating pain from lower body upwards, severe at times. Lasted about 3 days from day 4 of injections. It’s a normPersevere side effect but not nice at all. I could barely walk at times. Please know that it is not for ever, take strong painkillers eg cocodamol 30/500 if able to as this helped me. Also take laxative as cPersevereld get constipated. Best wishes Persevere

  • Thanks a lot for that! Blush

  • And best of luck on your journey! 

  • Hi. Your reply has made me feel so much better about this. In fact 3 days after the last injection I am much better. And it's good to know it doesn't last forever. Just one question: do you have Gilbert's Syndrome? I do, and I think it may have played some part in my reaction.

    All the best in your journeyHeart️

  • Glad I could reassure you, take analgesics day before you start next course and take them regularly, don’t wait for the pain before taking. No I don’t have GS x

  • Hello Jasa, 

    I am so glad to read this - well, I'm sorry you are having such bad symptoms, of course -  but I am suffering from the same achiness and crushing fatigue.  I had cycle 2 of 4 x EC and I feel as though, nearly a fortnight after, I am still feeling rubbish.  Absolutely flattened.  Needing to go to bed and lie down for hours after the slightest exertion.  Defo more than a bit poorly.  

    I feel like I will hardly come up for air before my next infusion....   I am keeping a symptom diary and I am going to ask my oncologist about it before my next cycle - how necessary/integral it is.  I guess it is finite, but it is very hard to function.  

    So, you have my sympathy and I feel your pain.  Best of luck. 

    Lisa