ER positive Her Negative metastatic breast cancer in bones

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  • Primary breast cancer in 2016. Lumpectomy, radiation and Letrozole. July 2025 lesions found on MRI for something else. Confirmed MBC in October 25. Retired 73 years old. About to start Denumosab and Radio to sacrum plus Letrozole Sacral lesion causing bladder and bowel irritation. Anyone else experienced this?