Kras Mutation Present

Hi . I’m afraid I don’t know anything about Kras but hopefully someone better informed will be along shortly. Have you had a look on the Bowel Cancer UK Board as well as I know there’s quite a few posts on there if you type kras in the search box?

https://community.bowelcanceruk.org.uk/forum/15657-explain-the-kras-mutation

Hope this helps

Karen x

Hi Karen

Nope I've not looked at Bowel Cancer UK website. I shall check it out. Thanks for letting me know about it (that's a big help in itself already).

Like you said hopefully someone else may be able to offer more advice/info.

Thanks again

Keep safe & well

Mark

Hi Mark ,

My very simple understanding is it’s a group of gene mutations . They make some forms of treatment less effective so they would probably not include them in your treatment regime and focus more on ones that are effective . Mainly biological agents that are ineffective! However you will see on forums patients using Avastin . Some are self funding this and there is a lot of research on line . 
Just to put it into context as people can feel a bit concerned at the thought of treatment options not being as broad . None of them were available when my mum was diagnosed and she only ever used straight forward first line chemo .

You might also like to find out if you are MSI as that opens up immunotherapy options for the future .

You might like to read up proper articles which I am sure explain it better but I think that’s roughly the deal .

Hope your well ,

Take care ,

Court 

Thanks as always Court, I hope you and your mum are well

All the best

Mark

Hi Mark

The information I have on KRAS 

Mutation in a signalling protein - some cancers can be damage (a mutation) in the proteins that transfer messages to the Nucleus (centre of the cell).  These signalling proteins including BRAF, KRAS and MEK, are known to be mutated in certain cancers so that the signalling pathway is continually produced, even in the absence of a  (ligand/receptor interaction) signalling pathway inside of a cell

There are drugs designed to inhibit the action of this mutated protein.

I hope it helps.

Take care,

VickiLynne

Thanks VickiLynne & everyone else. It's a little clearer now. 

Take care all

Mark