Hello
A colonoscopy discovered polyps in my colon and rectum and a tumour in the caecum. I had a colon resection a month ago removing the tumour, the caecum, ascending bowel, appendix together with lymph nodes, one of which was cancerous. According to the consultant surgeon, even though from the histology of the polyps they appear benign, one large one may be cancerous internally. I am due to have an endoscopic excision of the polyps immediately followed by starting 3 months' chemotherapy.
The oncologist registrar, while recommending chemotherapy to reduce the possibility of recurrence from about 30% to about 22%, stated that the operation had been successful and the cancer had been removed. When I repeated the surgeon's opinion that the large polyp might contain cancerous cells he said that would not make any difference to the recommended treatment by chemotherapy - 4 of 3 week cycles.
What I don't understand is the mechanism of how chemotherapy prevents the recurrence of cancer cells. If the resection has removed all the cancer cells in my body what will chemotherapy do? If it prevents cancerous cell division, how does that work if there are no cancerous cells present? If it turns out that a polyp is cancerous surely that will effect the treatment I should have?
Thanks in advance.
Hi ,
My understanding is that the reason for the chemotherapy is the fact that cancer was found in one of the lymph nodes. This basically means that the cancer had started to "travel". In all likelihood it was probably one of the lymph nodes closest to the original tumour, and the cancer may not have gone any further than that. But once in the lymph nodes, they cannot be 100% sure that there are no microscopic cells lurking around elsewhere waiting to cause havoc. The chemo is a "belt and braces" approach, i.e. they are relatively confident that all cancer has been removed, but they cannot be absolutely sure.
In my particular case the tumour had not breached the bowel wall and there was no sign of cancer in any of the lymph nodes, blood, etc. So I did not need chemo. And just for my peace of mind I sent the histopathology report to a friend who is an oncologist in South Africa, and he agreed with that assessment.
All the best for the chemotherapy!
Yolande
Hi . As Yolande says, it’s the sneaky lymph node that causes the recommendation for chemo. To pinch dom1969s favourite analogy - Cancer is like a weed. Imagine the tumour to be like a dandelion that’s just turning to clocks. You (the surgeon) dig out the dandelion and a fair bit of soil with it (remove the tumour with clear margins) however you find a clock in amongst the soil that you’ve dug out (lymph node). You cannot see anymore clocks round about but could one have been taken by the wind and is lying somewhere else in the garden and may take root? To be on the safe side you blast the whole garden with weed killer (chemo)
So Yes it’s the belt and braces - chemo isn’t pleasant but it is doable
Take care
Karen x
Hi
As others have said, it is the risk that there are microscopic cancer cells lodged somewhere that are currently too small to see/scan. With regard to the polyps yes sometimes there are small changes within them that make them turn cancerous over time. Best to get them removed pre-chemo, as you can't have surgery immediately after chemo as chemo reduces healing until it's effects wear off. As the oncologist said, whether the polyp as cancerous or not (you won't know if it is until you get the pathology report back after the op) the treatment would still be the same which is mop up chemo which you are having anyway because of your lymph node being positive.
Nicky
ha ha and here I am lol...hope you are keeping well karen!
Padraig, the chemo targets ALL fast dividing cells as that is what cancer cells do, so your hair may thin and youll probs get a sore mouth and feet ect.
It can be horrible and generally is to be honest but it will soon be over and youll be right as rain by christmas
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