trifluridine/tipiracil (lonsurf) with bevacizumab (avastin)

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My mission this week has been to give my Oncologist a headache. 

I've been placed on Lonsurf with Avastin after two lines of chemo last year that didn't help lung metastases much. 

My oncologist seemed pessimistic today as if this new like of chemo is literally just to make you last a month or so longer than having nothing at all. 

So I'm here to hopefully, keep an update to give anyone else any information and hopefully please share any experience you've had on Lonsurf with Avastin too. 

There didn't seem.to.be much information from my oncologist when I asked. 

Thanks! Neil 

  • Hi  I’ve personally no experience of this chemo but if you type Lonsurf and/or Avastin in the search box at the top left of the screen then it will bring up previous posts? I think the most recent one was  

    It would be good to have some up-to-date feedback so please let us know how you get on?

    Take care

    Karen x

    Macmillan Support Line - 0808 808 00 00, 7 days a week between 8am-8pm
  • My Oncologist started me on Panitumab in May 2022 for Metases on the lungs following a bowel resection in 2014. My CT scan  in August 2024 showed the Nodules had started growing again so in October i started on Lonsurf and Avastin, thankfully when I had my January scan some of the Nodules had shrunk. Now continuing with the Lonsurf and Avastin. The only trouble is when I staretd this cycle the hospital was not able to supply enough Lonsurf to complete the cycle and they would ring me when they had some, I rung M onday and they still didn't so will ring again today as my supply runs out today.

    Francis 

  • Additionally I think I have less side effects than on the Panitmab regime

  • My husband starts Longsurf and Avastin today, just getting ready to go to the hospital. Good to know you have had some shrinkage Heart

  • Hope everything goes well. I joined a local Macmillan group and it comes with a half hour gym session each week. So far on a week of Lonsurf I feel okay.... Gym excersizes completed slightly better than last week. No main side effects to report. But my doctor wouldn't let me take the IV Avastin this week because of an open wound from.my surgery in December. So fingers crossed next week goes well. How are you both coping?

  • That lines up with my experience so far. No side effects of the Lonsurf to report really. Hopefully it's still working though