Chemo dose reduction

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Hi everyone

I've got my fourth and final Capox round starting tomorrow. Saw the oncologist today and she decided to reduce the dose to 80% (both oxi and cape) as thought I was struggling with side effects (fatigue and some feet issues). She's assured me this is fine/will still be effective, and I have to say I'm glad of it as was dreading tomorrow (still dreading it, just slightly less!). I hope this takes the edge off the final round, or at least stops it being worse than the previous ones.

I'm just interested if anyone else who had a similar dose reduction did find the side effects eased a tiny bit? I'm still expecting to have them, obviously...just hoping I might find this last one a bit less gruelling than I was expecting.

  • I was due 4 rounds of capox.they dropped the oxy completely on the last one as I had lost my hair.but upped the cap dose.I had much less side effects and am now 5 yrs later discharged and doing ok.hope that helps.

    Kath

  • I had 6 rounds of capox, reduced to 80% for the last 2 rounds.  (struggling to remember if it might have been reduced from round 3).
    I was getting some foot/leg issues and pooing to a point of not being able to stop it when they reduced my dose.   The reduced dose (and codeine for the poops) made it easier to cope with.  I still couldn't walk after infusions even with the reduced rate.    I do have neuropathy now in hands and feet, but on the plus side, I did have a good response to treatment. 
    Nutshell, yes reduced dose should help with side effects, but you might still develop others.  You are nearly there though, so best wishes Betty :)

  • They reduced my Oxaliplatin dose twice, cycles 3 and 4 of 8. I was given the option of dropping it completely after cycle 4 but chose to keep it. I was having terrible problems with the peripheral neuropathy. It did reduce those symptoms but the peripheral neuropathy worsened after treatment (a phenomenon called coasting). 

    I am happy with my progress and am hopeful for a NED on my first surveillance scan. I'll get those results next week. 

  • I had my last two doses of oxaliplatin reduced by 20% as they were worried about neuropathy and the side effects were defintly less severe after both rounds, my arm was less sensitive and I just generally felt better in myself.

    Unfortunately I developed neuropathy in my toes after my last cycle that is still there 6 months later. 

  • Thanks for your replies everyone. Had dose reduced and definitely helped with reduced hand/arm pain after infusion (for Oxi) and I think slightly less fatigue with reduced cap. Still got the lingering slight queasiness and dry/peeling foot...but have my last tablets tomorrow (can't believe how many of the things I've taken in the last few weeks...over 400 of the buggers!) so hoping those things ease a bit after that.

  • Oh my! I daren't think about how many of those Cape tablets I took.   I know that in the final week I was tempted to just give up taking them, but I didn't.   Hated them with a passion as I'm sure you do.     I will be giving you a little cheer as you take the last ones. 
    I'm nearly a year after end of chemo.  I have neuropathy (I coasted)  and I am struggling cognitively, but I have had a good response to treatment so far in respect of my tumour.
    I have few veins left in my hands/arms, they've not come back yet after the oxy infusions.
    Just keep on being positive Betty!   
    Big hugs x

  • I had an allergic reaction to oxialiplatin as my first infusion stopped and allergy carried on for 3 days. I also had severe neuropathy in my hands and couldn't use my hands properly for 15 days.

    I have just been told my next infusion dose will  be reduced. I'm hoping this helps. Next treatment is Weds 6th May. I'm also hoping the reduction doesn't affect the treatment. Fingers  crossed.

    Good luck everyone x

  • Hi Betty I'm a bit late in joining group - I was left with severe neuropathy after 7 rounds of oxiplatin and 3 year later still suffer but take progablin which helps - I find the more I move the better it is - but I wish to make people aware with new airport fingerprint security -your fingerprint will NOT WORK if neuropathy in fingers as no blood supply !!! As for Chemo I'm on a reduced dose (50 percent ) and it seems to be working finger crossed best of luck and hope your coping better