What are the treatment options for pT3N1bL1V1

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.. and just like that we were called to see the Doctors yesterday. We were unsuspecting as we'd been told the biopsy results were due on the 27 December.

Well, they've come in. I have the report here with me, but the Lead Doctor basically said he recommends that for a quality of life my Dad (post-colectomy & anastomosis, and liver met ablation, Surgery on 19 Dec) just goes home and enjoys life. i.e.: best NOT to consider further treatment as on balance it will affect the quality of life. I asked what progression will look like and he said the metastases will cover the liver, likely over the next 5 years, leading to jaundice, then a coma. Death was gentle.

Daddy and I both were prepared for the worst, but hoping for the best. I'm not sure the information has actually sunk in / been processed. As all I can think of is how we will break the news to Mummy, likely later today.

The Report says: 

Specimen:...

1. 'Sigmoid colectomy.. of large ulceroproliferative growth ..in lumen... infiltrating pericolic fat 

2. Liver Met deposit - single, friable whitish tan tissue 1.2 cms

Microscopic:

1. tumour.. moderately differntiated invassive adenocarcinoma. Dense lymphocytic inflammatory response to tumour is seen.

The tumour is seen infliltrating muscularis propia and pericolorectal fibrofatty tissue.

Lymphovascular invasion is seen.

Perineural invasion not seen.

Tumor budding - intermediate score = 5-6 tumour buds/hot spot.

No tumor deposits seen. Mild serositis is seen. Mesocolon shows congestion. 

Proximal, distal, and radial margins of resection are free of tumor.

No polyps / additional features such as dysplasia / IBD / ulcertaion seen in the rest of colon.

Regional lymph nodes dissected show tumor metastases in 3 out of 6 nodes dissected.

2. Liver deposit biopsy - shows necrosed hepatic tissue infiltrated by metastatic moderately differentiated adenocarcinoma.

Impression:

1. Moderately Differentiated Invasive Adenocarcinoma

Pathological Stage Classificiation: pT3N1bL1V1

2. Liver Biopsy - Metastatic moderately differentiared adenocarcinoma, primary colon.

So, my question is has anyone been here? We're happy to NOT have further treatment (after all we all have to go some day) BUT we'd like to assess viable options that provide a quality of life and longevity of life.

(I'll share this on the diagnosis forum as well)

  • Hi  

    With the world of modern medicine being so online now have you thought about sending his report to a team in the U.K. to do a second opinion on ? 

    Just to reassure you my mum has never had post op chemo from both her liver resections . It came back after the first one and not the second . She has never had chemo after the lung surgery either and it took seven years to show up there again.

    This time she used a targeted treatment and had ten months of it. Our own approach which is purely personal but my mum’s first oncologist suggested we only target visible disease that is evident on scans so that’s been her approach. She had more spread at eighty and used a targeted treatment. But it did have some side effects that caused both my sister and l to wonder when do we stop this approach. That decision was taken outwith our hands and we are glad of that .

    But if you would like to think about potential options for the future there is that Avenue .

    For me we never think about timescales now . We just do as my dad suggested and take it on day at a time . 

    Take care and send your dad our best regards ,

    Court 

    Helpline Number 0808 808 0000

  • Thank you  your reply really helped me accept that this could be the best route after all.