Capecitabine and Oxipalatin

Hi PattyK. It’s a bit hard to quantify the success rate to be honest, I had capox after my operation as I had a couple of infected lymph nodes that had been removed. Capox was given as a ‘belt and braces’ proactive follow up treatment to zap any nasties that might still be floating around and I’m still cancer free 5 years later.

Capox is a tried and tested chemo that a lot of people have. Yes it’s a stronger dose of capecitabine and the oxaliplatin can have a few tricky side effects but it’s doable and worth giving it your (or James’s) best shot - if he really struggles with it then they can adjust the dosage or even drop the oxaliplatin but I looked on it as throwing everything I was offered at it.

Hope you’ve enjoyed a drink in the sunshine this weekend 

Take care

Karen x

Hi Karen! 

Thanks for that. Yes had a wee drink at the weekend. James seems a lot better now I've been looking at him the last couple of days and he seems to be `filling out` again if that's the right expression. He was looking a bit `scrawny` over the last couple of weeks but I think that was down to stress and worry. His arms looked quite thin as though he'd lost some muscle but they seem to be building again. Good that he's lost some weight though (a stone!) because he is a `big chunky bloke` but as I said the oncologist said he's not underweight so that's good. I now just want to get this started and hopefully they can start controlling whatever is there. He has to have a consultation with a urologist now I take this is to do with the scarring on his kidneys. That won't be until next month though and we see the oncologist inbetween then on the 28th of this month (July) so I'm really hoping they can get something going then. I just worry that the cancer is spreading elsewhere while he is waiting for all this to happen. He seems ok within himself now and is a bit more at ease now I think because they are saying they are going to do something. 

Vicky x.

Hi Patty

I have just finished Capox cycle 6...chemorad starting 18 July

Capecetibine was fine until day 12...of 14. Cumulative effects unpleasant but bearable .

Oxy. was very ,very nasty after cycle 4. The effect is cumulative. If it proves unpleasant early on that is the time to get a Port and switch to Folfox.

My understanding is that Oxy is useless by itself but facilitates Cap. Action. Surprised you were offered the latter without adjuvant. My understanding is that sole Cap. admin is usually refused.

Dosage is dependent on body surface area etc so if weight is stable I discovered that chemorad is 94 per cent of Capox dosage. Not much different which was an unpleasant surprise. 

Good luck on the voyage. If James does not have KRAS mutations then more targeted therapies might be worth exploring.  Adieu.XX

Thank You Anthony!

No he's not having chemoradiation this time. He had that prior to his operation back in January to shrink the tumour in order to remove it which was done successfully. I questioned the oncologist at one of his follow up appointments and asked if anymore chemo or radiotherapy sessions were needed incase of any wee `foreign nasties` floating around and he said no and if it is not necessary at the time to do it then they don't. But there you go the `wee foreign nasties` have made themselves present again and now he has to go through chemo again. He was on Capecitabine in tablet form the first time and the radiotherapy but this time the dosage of Cap will be stronger and again he'll get that in tablet form and the Oxy will be intravenous. Surgery we have been told is not an option at this time don't know if it will be in the future though. Just `champing at the bit` to get him started on this now the sooner the better. 

Vicky.

Lots of posts on here about capox.if you click on names you can see how everyone got on.

Kath

All the best

Thanks Kath! 

Yeah seen a few who have rated CAPOX as quite successful. Here's  hoping.