What is KRAS mutation

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Hi all. 

I saw on my notes about KRAS gene mutation, never heard of it, it's never been discussed with me. 

Have googled but still unsure 

Thanks all 

Bud xxd

  • Hi Bud, sorry I can’t be of any help, but wanted to say hello and send hugs xx

  • Hi , my Mum also has the Kras mutation, as do around 40% of ppl with bowel cancer so it's very common. 

    You can either be KRAS mutant or KRAS wild type. It is tested to guide the most effective treatment options for different patients depending on their tumour biology. It mainly means that the targeted drugs available on the NHS won't be used on you as they only generally work for KRAS wild type tumours. However, the standard chemo regimes such as Folfox and Folfiri are still very effective. There is a targeted drug called Avastin that works well on KRAS mutations but this is nor available on the NHS. 

    I'd say it is slightly better to be KRAS wild type due to their being more options on the NHS, but I don't think it has any significance on your overall prognosis.

  • Thankyou, will discuss with oncologist next time.

    Thankyou for sharing information with me, so much to take in xxddd

    Bud xx

    Xxxxx
    Bud 18