Cetuximab first, now Oxiliplatin, what next?

FormerMember
FormerMember
  • 2 replies
  • 112 subscribers
  • 602 views

Hi everyone

Had first treatment last year, T4a N2b M1, RAS wild type.

Cetuximab, NED at end of 12 sessions.

6 months off chemotherapy.

CT scan back with a vengeance, so now 12 sessions with Oxiliplatin.

FOLFOX now, first was FOLFIRI

Told change is due to rapid recurrence/growth 

Does this mean shorter life, or is it wait and see mid treatment and end of treatment with FOLFOX CT scan results, as may shrink back again more sustainably?

Worried and concerned Ian

Thanks for reading!

  • https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/chemotherapy-for-bowel-cancer

    If you click on the above link it shows you the names of the chemotherapy agents for bowel cancer . The oncologist can use different combinations to achieve shrinkage or stability . Sometimes they even go back and use combinations people have had in the past and call it “ repurposing “ . 
    What they hope to achieve is shrinkage or stability . Then they would possibly decide if a break can occur “ chemo break” or if a lower dose “ maintenance chemo “ is the best approach. To put that into context my mum’s liver had quite sizeable tumours . After chemo they could not see them on the scan . Six months later some had reappeared and she had more chemo . Again she responded and again no longer visible on the scan . Both times she got the same results ! The oncologist would have kept that approach going until they felt the chemo was not achieving as much and switch .

    Cell types matter in determining what combination is best . If biological agents are an Avenue they can also be included in the combinations and gives more treatment approaches. I think you have had some targeted therapy first time round in the Cetuximab so that’s good to know . 
    Just because some regrowth has occurred does not actually mean you won’t respond well . My mum’s oncologist explained that due to the rate of cell division it can work well in people who respond but have quicker growing tumours due to the rate the cell divide . I am not even going to pretend to understand that !
    So right now you have ever reason to be hopeful to gaining a response from chemo that will halt the growth of cancer and that is the hope ! The key is responding to treatment ! That’s what really matters in a stage 4 setting from what I can gather and it is only observations over the years and way too much reading research articles . 

    Some oncologists scan mid way through others just keep an eye on tumour markers . 

    Take care ,

    Court 

    Helpline Number 0808 808 0000

  • FormerMember
    FormerMember in reply to court

    Hi Court

    Many thanks for your helpful, informative feedback and support, it's really appreciated.

    Warm regards

    Ian