Intrahepatic cholangiocarcinoma & Capecitabine

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Hi,

I'm new to a forum of any kind!  So please bare with me.

My husband had 50% of his liver removed in mid September (left hemi hepatectomy) and has made a good recovery.   He is a very young & active 76 year old.  We felt we were very fortunate it was operable.  Despite the surgeon feeling confident the tumour had been fully removed the biopsy showed signs of perineural & lymphovascular invasion so he has just started Chemo, Capecitabine tablets.  I was wondering how other's have tolerated this drug and how soon he might start to feel any side effects?  And the outcome of anyone else who has had the same operation?

He is also taking part in a trial called ARTEMIDE for a new immunotherapy drug called Rilvegostomig.  It is blind so he has a 50% chance he could be given a placebo.  Perhaps someone else in this forum is also taking part?  (I hope I am allowed to ask this)

I know I should be patient and just see what/when he has side effects he has on the Capecitabine (and obviously everyone is different), I would just appreciate some forewarning as I have been told it's one of the better tolerated chemotherapy treatments.  I feel guilty it's a trivial question, my heart goes out to some of the people who have far worse situations.

  • Hello again Wazygoose,

    I'm so sorry to hear you are now experiencing a worrying time and glad you are managing it well.  

    When my husband was first diagnosed we did a little research but just went along with what the consultants recommended.  He was lucky that a trial was suggested & he decided to take part. 

    Since then I have been more pro-active on various sites.  Have you looked at the AMMF website which is dedicated to this cancer?  You can find info about molecular profiling which I had never heard of.  Professor Bridgewater of the UCLH seems to be one the leading specialists and from what I've read he sometimes works alongside local oncologists and gives advice.  He's also very proactive on trials & I think there is a large new one recently available.  Trials aren't for everyone, it's a personal choice, but you may wish to know your options.

    I'm hoping you won't need any of these things, and if you do, your hospital will be very knowledgeable all your options.  I've found the information very reassuring that if needed there are many routes of treatment.

    Sending my heartfelt wishes you have a good result from your scan.

    Looks like you are having a far sunnier day in Devon than we are in Norfolk!