Mum has a tough decision about targeted cancer therapy

Former Member
Former Member
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Hello, I’m new to this forum. My mum was diagnosed with stage 4 breast cancer 20 years ago! Amazing really. She’s been through a mastectomy, radio & chemo over the years, but for the last 10 years she’s been stable and only taking tamoxifen to keep the secondary bone cancer at bay.

Then 6 months ago she started having mobility issues, numbness down her left leg, and after a number of GP appointments she was diagnosed with secondary brain mets. She quickly had surgery to remove the tumour, which didn’t remove it all. A few weeks ago she completed 3 weeks of radiotherapy. Throughout this she’s been such a brick, staying positive and being a superstar.

unfortunately the radio hasn’t worked, so the next big step is targeted therapy. I can tell she isn’t keen because of the side effects. We have a meeting with the consultant on Tuesday. 

it would be really helpful to hear how others have found targeted therapy. I was hoping it might be less harsh than chemo, but from a Google search it looks like very similar effects. 

Thanks very much

  • Hi  and welcome to the Online Community although I am sorry to hear about your mum’s diagnosis.

    A cancer diagnosis in the family can be such a stressful and challenging time but I do hope you will find the community a safe place to get support and ask your questions.

    The Community is divided into support groups (discussion rooms) and I see you have joined our Breast, secondary cancer group, you may also want to consider joining our supportive Brain, secondary tumours group. This is a safe place to talk to others who may have a similar diagnosis, treatment experience, to ask questions and get support from others supporting family.

    If you'd like to connect in with a group click on the Green (Bold) link(s) I have created above. Once the group page opens click on the black banner that says [click to join] at the bottom, or the [Join] button under "Group tools."

    You can then introduce yourself by putting up a ‘new post’ by clicking in the box near the top right with + New or + (Depending on the device you are using) and you are ready to go. You could copy and paste the text from this post into your new post.

    When it comes to the practical and emotional challenges of supporting someone you may also benefit from joining our general Family and friends group where you will connect with others navigating the same challenges.

    Macmillan have many support services so do check out the Macmillan Support Line is open 8am-8pm (timings may differ across services) 7 days a week on 0808 808 00 00. These services provide cancer information, practical information, emotional support, benefits/financial guidance or just a listening ear.

    We also have our Ask an Expert section but do allow a few working days for a reply.

    Talking to people face to face can be very helpful so do check to see if you have any Local Macmillan Support in your area, do also check for a local Maggie's Centre as these folks are amazing supporting all the family.

    Please do get back to me if you need further help.

    All the very best.

    Mike (Thehighlander)

    It always seems impossible until its done - Nelson Mandela

    Community Champion Badge

  • Hi - there are different types of targeted therapy, but I was really surprised to read your takeaway that targeted therapy is as harsh as chemo, because my understanding is that chemo is much more difficult to tolerate.  I haven't experienced chemo directly, but I am on immunotherapy (ipi/nivo a monoclonal antibody), successfully so.  There are lots of different targeted therapy drugs acting on different parts of the immune system and everyone responds in their own unique way.  Sweeping generalisation but my nurse specialist has said that people generally tolerate my drug well.  

    The predominant side effects I was warned about were diarrhoea, sickness and itchy skin.  I've had a minute amount of itchy skin, but nothing that has made me take anti-histamine.  I've had a less frequent immune related adverse event causing impaired kidney function, but back on schedule now.   

    Do you know the drug under consideration?  I'd suggest you put it in the search window and find specific experiences for it.  Also, I'm not BC and my metastasis is in lungs.   I'm a fan of immunotherapy because it's shrinking my tumours so rate my response accordingly!  All the best to you.  xXx

  • Former Member
    Former Member in reply to Mmum

    Hi there, thanks so much for your message, it’s great to hear you’re having a positive experience with immunotherapy, best of luck with your treatment.

    The drug is Abemaciclib, good idea to see if others on this forum are taking it, I’ll see what I can find out. Also we have a meeting with the oncologist next week so I’m hoping she can be reassured to give it a go.

    Thanks again, very best wishes x 

  • Former Member
    Former Member in reply to Thehighlander

    Thanks Mike, really appreciate the advice and your offer of support. I’m glad I joined this forum, I’m already feeling more positive following your message and the one from Mmum. 

  • Hi again, I have just done a search of the site and got a few hits on the word Abemaciclib.

    So go to the search Mag tool near the top of the site, put in Abemaciclib and select Anywhere. This will bring up all the posts and as always you can not reply and see if the members are still using the site ((hugs))

    Mike (Thehighlander)

    It always seems impossible until its done - Nelson Mandela

    Community Champion Badge