Diamond trial.

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hi everyone I’ve posted before about having METAPLASTIC breast cancer that has now metastasized to my lungs I was told I potentially only have a year and I’m a single mum to a almost 3 year old.
Today I met with the consultant at St Barts hospital for talks about the new trial called the Diamond trial it’s a new kind of immunotherapy called Durvalumab either on its own or with Datopotamab deruxtecan .

He said it’s having good results potentially better than the sacituzab but they haven’t treated many cases where cancer has spread within 6 months. I’m so scared I thought I’d feel more hopeful after speaking to him but I really don’t. Has anyone else had their cancer spread so quickly and are having good results with other treatments?

Stella2020 8 days ago

Have you cross posted in the breast cancer forum? They may have more experience there. But the trial is sounding promising! It is a phase 2 trial that means so patients have already had them before you and showing good safety profile and potential clinical efficacy. A drug typically would cost around several hundred million to 1 billion dollars to get to phase II trial so they don’t undertake them lightly.

All the best !

Stella x

Penguin80 7 days ago in reply to Stella2020

Hi Stella, no I haven’t. Thank you. I will try and do that yes, it’s a phase 2 trial. I think he spoke so quickly as his secretary had forgotten to actually book in my appointment so when I got to the hospital, they didn’t know who I was even though he knew I was coming, so it was all rather a blur

Coddfish 5 days ago

Clinical trial nerd here. I think this is the trial your oncologist is referring to. https://www.isrctn.com/ISRCTN67463316

it’s looking to recruit 140 people. I hope you are successful in getting a place. The early results for datapotumab deruxtican have looked good, it seems to cause fewer toxicities than sacituzumab govetican; both of these drugs target TROP2, which most TNBC has.

Penguin80 5 days ago in reply to Coddfish

Thank you, I’ve got all the scans and tests next week so hopefully my cancer hasn’t spread any further than my lungs as that would be the only reason I wasn’t eligible the oncologist said. I feel so fit and healthy which makes this so much harder to believe.

Coddfish 5 days ago in reply to Penguin80

sounds promising @Penguin80