B7-H3 Testing

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Has anyone had their tumour tested for presence of B7-H3 please and if so where did they send it to get it tested? My 13 year old daughter has a rare round cell sarcoma and we are looking at potential trials for CAR T. One of them is in the US and needs the presence of B7 H3 (CD276) but we were hoping to speed things up by doing the pre-testing in the UK. Our current hospital network cannot test for this (RBOH, UCL and Royal Marsden). It was not covered in her original histology and genome biopsy testing. Any help greatly appreciated

  • Hi  and a very warm welcome to the online community which I hope you'll find is both an informative and supportive place to be.

    I'm sorry to read that your daughter has round cell sarcoma and it's natural to want to explore every avenue of treatment.

    As the online community is divided into different cancer specific support forums, I'm going to recommend that you also join either the soft tissue sarcomas forum or the bone cancer forum depending on which type your daughter's sarcoma fits into. You'll then connect directly with others who may have had the test you're asking about.

    To join, just click on the link I've created and, once you've joined, you can start a new post in the same way as you did here and join in with existing conversations by clicking on 'reply'.

    It would be great if you could put something about your daughter's diagnosis and treatment to date into your profile as it really helps others when replying to you and also when looking for someone on a similar pathway. It also means that you don't have to keep repeating yourself. To do this click on your username and then select 'Profile'. You can amend it at any time and if you're not sure what to write you can take a look at mine by clicking on my username.

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