Perineural Intrusion

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I was diagnosed with Prostate Cancer Gleason score 6 last Friday.

The report said perineural intrusion was present

My doctor said the cancer was slow growing and suggested Active Surveillance,but I wondered what the significance was of Perineural Intrusion on the report. 

Your advice would be appreciated 

Many Thanks

  • Hello Nijinsky,

    Thanks for contacting us. I’m Gail, one of the Cancer Information Nurse Specialists.

    I am unable to find information on the term ‘perineural intrusion’ but the description perineural invasion is commonly seen on pathology reports. I suggest you check with your doctor for the exact wording of the pathology report or request a copy of the letter sent to the GP by your Urology team.

    The investigations you’ve had to diagnose your prostate cancer will have provided your medical team with the information they need to advise you on ongoing management

    Perineural invasion means the cancer cells were seen surrounding or growing alongside a nerve fibre within the prostate. The presence of Perineural invasion would be taken into account when the treatment options were considered by the Urology Multi-disciplinary team. All the information included on your pathology report would be taken into consideration, when assessing the risk of there being a higher chance of the cancer spreading outside your prostate.

    If you have any questions about your results or the medical management suggested, you should discuss them further with your Urology Nurse Specialist, Urology Consultant or GP.

    I hope this information is helpful. If you have any further questions, please get in touch by email, webchat or phone. The Macmillan Support Line offers practical, clinical, financial and emotional support. You can call us free from landlines and from most mobile phone networks* on 0808 808 00 00, 7 days a week, 8am – 8pm. You can also visit our Online Community, where you can talk to others who have been affected by cancer. 

    Best wishes,

    Gail

    Ref: GH /GeS