CIN progession

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I have been diagnosed with CIN3.

I had CIN2 about 12 years ago and since then have attended all my smear appointments.

In April 2023 I had low grade abnormal cells not requiring treatment, fast forward less than 18months later I have CIN3.

My understanding from what I have read is that CIN changes are slow with time frames for untreated change being about 5 years.  

I am trying to make sense of this trajectory, does it have any implications moving forward?

  • Dear  

    Thank you for getting in touch and welcome to our Online Community, I’m Sue one of the cancer information nurse specialists.

    I’m sorry to hear you have been diagnosed with CIN3 after being told 18 months ago you had low grade cells, not requiring treatment. Cervical intraepithelial neoplasia (CIN) is a term that describes abnormal changes of the cells that line the cervix. It is important to remember that CIN is not cancer. 

    It’s understandable you are trying to make sense of things. It’s good you have continued with having your cervical smear tests over the last 12 years since being told you had CIN2.

    While it’s not fully understood how the cervical cells change over time, its widely accepted that there is usually a gradual progression from CIN 1 to CIN 3. However, there are research studies that have found CIN 3 can appear by chance, without a previous finding of CIN1/2. So, the trajectory of your smear findings from 18 months ago to now may have no implications at all.

    CIN 1 often goes away on its own by the immune system getting rid of it. The plan for repeat smear tests and/or for any treatment to remove abnormal cells will also depend on whether you are found to have one of the higher risk HPV types. Abnormal cells can be removed during a colposcopy to reduce the risk of developing a cervical cancer.

    We always encourage discussing your individual situation with your GP and healthcare professionals involved as they are best placed to be able to answer any specific questions you may have. Do take a list of questions to your next appointment.

    I hope this information is helpful. If you have any further questions, please get in touch by email, webchat or phone. The Macmillan Support Line offers practical, clinical, financial, and emotional support. You can call us free from landlines and from most mobile phone networks* on 0808 808 00 00, 7 days a week, 8am – 8pm.

    Sending best wishes

    Sue

    Ref: KH /SMG

    Sue Cancer Information Nurse Specialist