PREDICT Breast Cancer - Different versions

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My Oncologist has used PREDICT prognostic model to plan the course of treatment following a lumpectomy I had on my breast, a few weeks ago.

He has used the old version of the online model (v 2.2), recommending chemotherapy, radiotherapy and bisphosphonates treatment courses over the next 6-9 months. However, when I use the latest version of the online model, PREDICT (v 3.0), the result does not recommend chemotherapy (additional benefit <3%).

When I asked the specialist, he said the new model has not been endorsed by UK breast team (?) even though it is available online and fully recommended as an improved prognostic model by University of Cambridge breast cancer unit.

I am interested to know other clinicians' opinion about this and why the new model may not have been endorsed. This is a big dilemma for me, as I don't really want chemotherapy if the harm from the side effects outweigh the benefits, as shown by the latest PREDICT result in my particular case.

I would be grateful if you could share any information on the latest status of PREDICT use by the specialists across the UK.

Best regards, 


  • Hello Katay

     Thank you for contacting us at Macmillan. My name is George, and I'm one of the Cancer Information Nurse Specialists on the support line. This is an interesting question which I have asked the wider Macmillan support team. Unfortunately, we do not have access to NHS medical records, so we cannot confidently answer this question. I acknowledge that the same tool, different versions, and different treatment suggestions can confuse and concern you.

    I have observed that the Cambridge University website discussed data they compile over time to substantiate the accuracy of this tool and its versions and thus change the tool accordingly. It may be that some practitioners are using the verified and evidence base regarding version 2 until enough data is back regarding V3. However, I would not be able to comment further, and this could be a question to pose to your consultant to explain their rationale in determining your plan of care and why they feel that using V2 of PREDICT Breast Cancer is better at doing this over V3.

    I can't find any further information about this, but you could always contact the Nurses at Breast Cancer Now in case they have any further information that may help with your question.

    I hope this information is useful. Please don’t hesitate to call to speak through your concerns or any current anxieties. If you are unable to call, you might consider speaking to us via webchat.

    The Macmillan Support Line offers practical, clinical, financial, and emotional support. You can call us free from landlines and from most mobile phone networks on 0808 808 00 00, 7 days a week, 8am – 8pm.


    Kind Regards George

    Cancer Information Nurse Specialist 


    Ref GH / HeP