Anaphylaxis shock to both Paclitaxel & Docetaxel

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I had a robotic full modified hysterectomy in April which went well and I felt brilliant. My consultant called to say although they had removed all the cancer and the 13 lymph nodes that were also removed came back clear, I would need Adjuvant therapy. My treatment was to be 18 chemo sessions weekly over 18 weeks then 25 External beam radiotherapy followed by 4 sessions of Bracytherapy. I started Adjuvant chemo therapy on 3rd June where after 4 mins of Paclitaxel I encountered an anaphylactic reaction. Hot, dizzy, chest pains, swollen throat and face and extreme kidney pain (like a tens machine on full), I was given the drugs to bring me back to normal but suffered low heart beat and oxygen levels which caused me to be unconscious. The team were brilliant and very professional. I saw my Oncologist the following day who then put me on the synthetic version Docetaxel. I went for this infusion yesterday and again the same thing happened. I am due to see my oncologist on 21st June but am now worried that there wont be an alternative for me. Am I likely to be offered any other  treatment or is there any other treatment? Im getting quite worried I wont be able to get treatment. Any advise would be welcome. Thank you 

  • Hi Edgecumbe girl,

    Thanks for getting in touch, my name is Sarah one of the nurses on the Macmillan support line.

    I’m sorry to hear you have reacted to 2 different chemotherapy drugs. That can be a very scary experience and it’s good to hear the chemotherapy team were brilliant and professional. Reactions to drugs are rare but can happen with both Docetaxel and Paclitaxel.

    It’s natural to worry about whether any other treatment’s may be available. Your team will make decisions about treatment based on your diagnosis and results following your surgery. They will be weighing up the benefit of having any treatment against possibility of any other further reaction.

    There can be alternative drugs or they maybe able to try one of the drugs you have reacted to as a desensitising regime where the drug is given in small amounts over a longer time. Here at Macmillan, we can give general advice and support. Your team will be best placed to answer your questions about what is best for you.

    Whilst you wait for your appointment, write down your questions so you feel after your meeting you understand the options available. Also take care of yourself and stay well so you are ready for any other treatment they may offer.

    I hope this information helps. Please feel free to get back in touch if you want more information or support.

    Best wishes,

    Sarah

    Cancer Information Nurse Specialist 

    REF: UH/SS

    Sarah S-Macmillan Cancer Information Nurse Specialist
  • Hi Sarah and thank you for your quick response. At least I know now that there are other treatments out there that may be able to help me to continue my journey. This has helped me a lot knowing this.

    I will begin my list of questions and take them back to my oncologist next week and will repost here in the hope that the answers I get may help someone else going through the same situation as me

    Thanks again for your help 

    Jane x