Long term use of niraparib

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Hello

My wife who had stage 4 ovarian cancer has been taking niraparib for about 5 years. She has had, since the original diagnosis,  2 sessions of chemotherapy, the second following an operation to remove numerous tumours. It has been a great success and all scans since then have shown no sign of the cancer returning. She is back to playing golf twice a week and is physically active. Great news for which we are incredibly grateful. In the last 18 months she has though struggled with a persistent cough that never clears and an increasing level of severe tiredness, both of which are shown as side effects of the drug. Blood tests every 2 months show no problem. Our GP has had sputum analysed and given the all clear. Neither of us or her consultant would countenance stopping the drug. We feel extremely lucky but it would be interesting/reassuring to know whether there are others in a similar situation and whether anyone has done anything to help cope or deal with these effects. 

  • Dear Misfitmike,

     

    Thank you for contacting Macmillan. My name is Denise and I am one of the Cancer Information Nurses working on the support line. Thank you for joining the online community and I hope you find it useful.

    I am sorry to read your wife was diagnosed with stage 4 ovarian cancer and had to undergo numerous treatments. It is good to read she can play golf and is physically active.

    Unfortunately, cough is a known side effect of Niraparib, and I was unable to locate any material about strategies which may help. It is up to her consultant to weigh up the benefits and risks involved but it is not unusual needing dose reduction if side effects are significant and are causing other health problems.

    As we do not have access to NHS records, we cannot be very accurate. The best person to talk about this is your wife’s consultant. Her doctor can check if she has other health conditions or medications which may contribute to this and make changes if necessary. If your wife’s symptoms are getting worse, I would suggest not to delay seeking help from her team but consult with the medics as soon as possible.

    I hope this information is helpful. Please do not hesitate to get in touch with us if you have more questions.

    Best wishes,

     

    Denise

    Cancer Information Nurse Specialist

    You can also speak with the Macmillan Support Line team of experts. Phone free on 0808  808 000 ( days a week, 8am – 8pm) or chat to us or send us an email.

    Ref: DK/LiR