Excess saliva production - oesophageal cancer

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Hello,

I wonder if you can help. My mother (now 90) was diagnosed with oesophageal cancer (adenocarcinoma, signet ring cells) at the junction of the oesophagus with the stomach, in July 2023. She has responded very well to chemo and had the full 6 cycles. That ended just before xmas. She is still doing well, but she does have issues with excess saliva (not vomit, nor regurgitation of food, nor acid reflux) triggered by seemingly random food. This is the symptom that first drove her to seek help. She isn't in pain, but it is making her reluctant to eat in case it starts off one of these 'episodes'. She has been prescribed Amitriptyline Hydrocholide as an alternative to patches behind the ear (hyoscine patches?). But I can't see in the info about the drug why this might work - there is no mention of it controlling saliva production. Just checking there has been no misunderstanding.

Many thanks

  • Hello HMP,

    Thanks for getting in touch with us. My name is Linda and I’m one of the nurses on the Macmillan support line.

     

    It’s understandable that you are looking to double check the use of the medication- Amitriptyline hydrochloride to help relieve saliva production.

    When it is taken orally it blocks a receptor called acetylcholine in the salivary glands which helps to reduce the saliva.

     

    This NICE(National institute for clinical excellence)- palliative care guidance shows that Amitriptyline can be used for excess saliva.

     

    I would encourage you to discuss it’s use with your mum’s cancer team, just for your own peace of mind.

     

    I hope this helps and it’s good to hear that your mum is doing well otherwise.

     

     

    Best wishes,  

    Linda J. Cancer Information Nurse Specialist  

     

    You can also speak with the Macmillan Support Line team of experts. Phone free on 0808 808 0000 (7 days a week, 8am-8pm) or send us an email.  

    Ref: LJ/DK