My partner was diagnosed with AML TP53 double mutated variant and after the first cycle of an intensive chemo they have stopped all the treatments. I was wondering if he would benefit from immunotherapy. It is extremely expensive so I just want to know should I try and find the money for it or there is no chance that it work. 



  • Hi MZK,

    Thank you for getting in touch with Macmillan Cancer Support. My name is Anne, and I am one of the Nurses on the Support Line. I’m very sorry to hear that your partner was recently diagnosed with AML. This must be a difficult time for you both.

    I understand his treatment was stopped and you are wondering if he may benefit from immunotherapy. Treating patients with tumour protein p53 (TP53) is particularly challenging. Studies have shown that they don’t always respond well to intensive chemotherapy, which is the standard treatment option. Research into more effective treatment options for this challenging AML subgroup is needed. There is a recent study looking at emerging treatment options which you may wish to read and then discuss further with your partner’s team.

    As we are not directly involved in your partner’s care, we would suggest you speak to his healthcare team at the hospital about other possible treatments. You can either contact his Consultant or his Clinical Nurse Specialist (CNS) to arrange a consultation. They are best placed to advise him about any other options which may be available. It may be worth enquiring about clinical trials for AML. Blood Cancer UK has information on understanding clinical trials and it may be helpful to read through their information.

    Supporting someone with a leukaemia diagnosis can be difficult. It’s important to look after yourself too and reach out for support if you need it. Our Support Line is open every day from 8am until 8pm if you feel you may benefit from a chat.

    Take care for now,

    Anne - Cancer Information Nurse Specialist


    You can also speak with the Macmillan Support Line team of experts. Phone free on 0808 808 0000 (7 days a week, 8am-8pm) or send us an email.


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