Genetic link

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Hello,  

My mother, my sister and both of my grandmothers had breast cancer and I have had it myself.  My father died of cancer of unknown origin when he was in his early 30s.  My sister had cancer in both breasts and was high risk, but mine was caught at an early stage. We were both 50 at the time but, thankfully more than 10 years on, we are both well. My sister had a bilateral mastectomy and reconstruction and I had a lumpectomy.  My mother and grandmothers survived following treatment  and died of other causes. I was having yearly MRI scanning but have now decided to have mammograms instead.  My recent mammogram was clear.  We were tested for BRCA genes about 10 years ago but this was clear.  My questions are  - is this level of family involvement unusual? If so, what type of genetic mutations may be involved? More importantly, should I be having yearly mammograms due to my risk?  I realise this question is quite specialist but hope you can help. 

Gail

  • Hi  

    Thanks for getting in touch and welcome to the online community, I hope you find it supportive.  My name is Gillian and I’m one of the Cancer Information Nurse Specialists on the Macmillan Support Line.

    I am pleased your recent mammogram was clear; it is understandable that you are concerned regarding your screening given the number of family members who have had cancer.

    A possible cancer genetics link may be highlighted when several family members (on one side of the family) are seen to have been diagnosed with the same type of cancers and diagnosed at a younger age.

    Some people have a higher risk of developing breast cancer and possibly other cancers because they have inherited an altered gene. An altered gene may also be referred to as a gene change, variant or mutation. It may be reassuring to know, that only 5-10% of cancers happen because of an inherited faulty gene. This means that 90-95% are not genetically linked.

    The most common inherited altered genes that increase the risk of breast cancer are called BRCA1 and BRCA2 (BRCA stands for BReast CAncer). I see you have already been screened for this in the past.

    You may wish to discuss having a referral to  a genetic counsellor  regarding this history. A referral can be made by the Consultant or your GP.

    This is discussed further in our booklet, Cancer Genetics-how cancer sometimes run in the family. It can give you further advice and information while you reflect on your own family’s cancer history.

    As we are not directly involved with your care and unable to access NHS records, we are not able to comment on your specific circumstances. We would suggest you contacting your GP or breast care team to discuss the best screening for you individually.

    Breast screening recommendations will be based on National Institute for Health and Care Excellence (NICE) National guidance Screening recommendations.  I hope this is helpful.

    Please don’t hesitate to get back in touch at any time.

    Best wishes 

    Gillian

    Cancer Information Nurse Specialist 

    You can also speak with the Macmillan Support Line team of experts. Phone free on 0808 808 0000 (7 days a week, 8am-8pm) or email us. 

    RefAC/GG