New to this group but about to start my second round of chemo for bowel cancer. Tumour has been removed but there are still traces in lymph nodes and blood. Have had a PICC line installed and understand the course comprises 12 cycles of two weeks with me being on half dose due to a low DPD. I am scheduled to go on holiday after the seventh dose and wondered if it was okay to then take a four-week break before completing the course. Will this break in treatment mean there is a lower chance of success? Should I cancel the holiday?