Side effects of Aromatase Inhibitor

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I have been taking Anastrazole since the autumn of 2014 following a diagnosis of aggressive and invasive breast cancer. I have had 3 lots of surgery culminating in a mastectomy. I've had chemotherapy and injections of Herceptin.   I was expecting to be taking Anastrazole for 5 years but, at my last appointment with my consultant in September 2019, she advised a further 3 years on Anastrazole, as new research had revealed that it was beneficial to take it for an extended period.  I am aware of the side effects, in my case mostly bone and muscle pain and have very largely put up with them but since last summer and especially in the last 3 months these symptoms have been excessive, I am in pain most of the time and my hips ache even when lying down.  The muscle weakness especially in my legs is making me nervous, I am used to playing quite a lot of sport.  My GP has prescribed co-codamol but I am reluctant to take this, I do so sometimes.   I guess my question is: if I stop taking Anastrazole will all of the pain and muscle weakness go away?  My consultant appointment is a way off, should I wait to check until I see her?  She did promise me a DEXA scan.  Your thoughts and advice are very welcome.  

  • Hi Joules,

    I’m Kirsty one of the cancer information nurse specialists. Thanks for getting in touch at what sounds like a difficult time for you.

    Although a known side effect of Anastrozole is unfortunately muscle and joint pain, we always hope that this remains at a manageable level and is helped with painkillers. I understand your reluctance to use the co-codamol regularly but wonder if you might be open to try to take it as prescribed – even for a few days. This would allow you to assess how effective they are and if perhaps the co-codamol would be an option that allows you to continue with your hormone treatment, for the extended three years.

    Sometimes it is possible to change to another hormone treatment, which may lessen side effects. Another option for you to discuss with your consultant, at your next appointment.

    Chronic pain is wearing, and I can hear how exhausted you are. Stopping treatment should only be considered after a consultation with your specialist, where you weigh up the benefits of continuing and the side effects you are coping with. This would usually be a last resort, perhaps after trying the suggestions above.

    Before making this informed decision, perhaps suggesting a small break from treatment beforehand, would allow you to compare and assess your pain levels and decide what feels right for you. Keeping a pain diary is a great way to assess pain.

    The DEXA scan you mention is to look at your bone health because of your risk of osteoporosis. This is a completely different concern but will give some additional information when considering treatment options.

    I appreciate that perhaps although struggling with pain, you had an end of treatment point to focus on and were on a countdown which felt doable. With that date being extended, perhaps your pain suddenly feels overwhelming. Why not request an earlier appointment with your consultant or speak to your cancer nurse specialist about how you are feeling?

     

    Best wishes,

    Kirsty, Cancer Information Nurse Specialist 

     

    You can also speak with the Macmillan Support Line team of experts. Phone free on 0808 808 0000 (7 days a week, 8am-8pm) or send us an email. 

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