Side Effects Between Cycles 4 and 5

1 minute read time.

Cycle 5 being done today (25/09/24).

Unfortunately Cycle 4 has been significantly worse, due to cumulative effects which are widely experienced - and other than mouth problems all others have persisted through the full duration of the Cycle.

Notable observations are:

NEW - SHORTNESS OF BREATH - first noticed slight on day 5 but gradually became worse and by day 10 was intrusive walking up slopes. By day 15 a dry cough developed and any activity other than a steady walk on the level caused heavier breathing. Consultant said in review on day 16 this was to be expected and consequent decline in excercise compounds it - as well as fatigue (see below). Sent for chest X ray (partly due to my lung cancer treatment 10 years ago). Day 21 and I still don't know the result - no news is good news but it does no good for my anxiety level and I'll try to find out at chemo visit today.

MOUTH - became sore again but was supplied with mouthwashes in advance so started using these before the worst symptoms appeared which had it cleared in 6 days. Will ask for same suppiles again today.

FATIGUE - much worse, started day 3 and became worse as time progressed. On day 17 I cut my grass and for the first time ever had to stop half way through each lawn for a rest. Now even walking an the leveI is very tiring. Again, a vicious circle because activity helps fatigue but also causes it so is very difficult! Just need to keep trying to push as far as possible. I hate being inactive!

HANDS - same as last time. 

WEIGHT - 3lbs lighter day 21 as on day 1. I'm pleased because exercise activity has declined significantly but I've maintained a very healthy diet as well as losing appetite on a few down days but probably offset by a few comforting G&Ts, beers and glasses of red (in moderation of course!).

EYES - remained watery throughout and becoming a real nuisance when outdoors, especially with temperatures dropping a little and generally breezier

HAIR - very thin but there's still some left. Definitely need a hat on these chillier mornings / evenings and dull / breezy days.

OVERALL - cycle 4 has much more difficult due to more intense and longer lasting side effects than 1 to 3. I'm quite nervous to see what Cycle 5 brings.

Anonymous
  • Good Morning Derek ( 

    I do hope Cycle 5 goes well.  Not only are you hitting the cancer had and fast - it's working for you plus your blog is helping others who may need similar treatment in the future. (I read every episode as those two words "biological recurrence" are at the back of my mind).

    The "fatigue" is a hard one - do you exercise and become more tired or do you try and work through it!!

    Keep it up - you are doing great.

    Best wishes - Brian.

  • Hello, I had three months of chemo last autumn (and having some more now) I found that each cycle was harder than the previous one. And, that the later cycles were very much harder, the last cycle was an absolute monster. It is most definitely cumulative! Keep a diary/log of symptoms and call your nurses if you get those amber or red flags. Well done on cutting the grass! Good luck. 

  • Thank you very much for the encouragement Brian, it helps very much.

    I know what the words "biological recurrence" feel like in the back of your mind, they were there with me for some considerable time, but until it occurs you're still doing OK. It's important we make the best of things and live life to the max. all the time. 

    My latest PSA is now less than 0.05, undetectable, another huge boost, one very lucky boy so far and very grateful form it.

    Side effects are definitely easier to put up with for such results.

    All the best,

    Derek.

  • Thanks very much Dignahtee.

    I too have had chemo before - in my case 10 years ago, adjuvant Cisplatin and Vinorelbine after surgery (right lung removed) for NSC lung cancer - and a very lucky survivor of this so far. It was difficult and definitely cumulative as you say. At least I did know what I might experience this time around and it's true to form.

    I do keep a daily diary as you suggest and would recommend anyone undergoing this to do so as I think it makes it easier to follow changes by cycle and therefore when to follow up in case of those flags.

    Thanks for the encouragement, I very much hope your current treatment goes as expected and with success.

    All the best,

    Derek.