Small cell prostate cancer treatments

Hi, does anyone have any experience with small cell prostate cancer treatments? Is it as aggressive as I have been reading about? What chemotherapy treatments have people tried? My father is on Etoposide and Carboplatin.  Is it normal to be completely non functional on round 1 chemo treatments?  Has anyone tried Zytiga ? I know zytiga is a hormonal therapy and apparently this is not successful with small cell.

Are there any clinal trials at the moment that perhaps I could enlist my father in?  I have read several journal articles none of which sound very positive and apparently there is no decided line of treatment except that it is simply treated as small cell lung cancer.  I would like to know if anyone out there has tried something other than chemo or radiotherapy?

  • Hi there,
    Welcome to the site. I'm sorry to hear about your Dad's diagnosis.
    All treatments for cancer can be pretty debilitating and some chemo regimes are more debilitating than others. If your father is feeling washed out this is not unusual, especially on chemo. He will be frequently monitored and the team looking after him will make sure he is well enough to receive the treatment.
    The general advice is listen to your body and if its saying rest, then rest!
    If you want advice on alternative treatments for small cell prostate cancer then the best advice is to talk to the specialist nurses on the helpline either here at macmillan or at the prostate cancer charity. The Internet has a lot oh information about cancer but not all of it is reliable.
    The contact numbers are:
    Macmillan 0808 808 0000 open 9am to 8pm Mon to Fri.
    Prostate cancer charity 0800 074 8383 open similar hours
    Both are free and the specialist nurses are very well informed.
    Good luck,
    Colin xxx


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  • Hiya,

    I'm really sorry to hear that your Dad has Small Cell Prostate Cancer. Unfortunately I know exactly what you are going through, but I don't think I have the answers you seek.

    My father has suffered from small cell prostate cancer since last March.  He has tried 2 different chemotherapy regimes (Carboplatin & Etoposide and CAV) and he is now considering a 3rd.  He had some radiotherapy to offer respite from the pain caused by the prostate tumor but only as palliative treatment.

    I have searched long and hard for information on clinical trials or any other treatment and turned up nothing. Don't give up! But if you do find something can you share it on here.

    If you have any questions please dont hesitate to make contact with me on here, I know what you are going through and how desparately lonely it is.  There are a few of us on here though, do a little search and you will find a couple of threads in which we have discussed treatment so far.

    Take Care, you and your family are in my thoughts

    S x

  • Hi

    Sorry to hear about your dad and his small cell PCa. Youre right - this is much rarer than many other types of PCa and doesnt respond well to the same treatments .

    There is not so much information about for that reason but Cancer Research UK site here has some reliable information.

    I suggest you phone the Prostate Cancer UK helpline specialist nurses

    Prostate Cancer UK helpline

    call 0800 074 8383 (free from UK landlines - Mon-Fri 9am-5pm Wed 7pm-9pm 

    Hope that helps

    Mal

    Macmillan helpline no. is 0808 808 00 00 (Monday to Friday, 9am–8pm).

  • Hi again,

    I forget to mention trials

    those underway in UK are listed on the Cancer research UK website trails page

    I had a brief look but didnt find any specific to small cell - but look yourself. But your specialist should know or again the Prostate Cancer UK specialist nurse helpline on 0800 074 8383

    Macmillan helpline no. is 0808 808 00 00 (Monday to Friday, 9am–8pm).

  • Hi sorry to hear about your Dad.Mine has small cell and first chemo landed him in hospital with a high temp for a week.He then had dosage reduced and completed the 6 lots.3months ago test showed a shrinking in the lymph nodes.He has pretty much carried on as normal (case of having too as mum was on chemo too)we are awaiting scan results any day now.Good luck to your Dad .Join us on Prostate cancer uk community too best wishes Paula xxxx

  • Hi Paula,
    I've got everything crossed for good scan results.
    Colin xxxx


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  • Hi Thank you for your msg. I hope the results from the scan are good news. Your msg gave my mum and I some positive hope for sure.  So your Dad completed 6 rounds of chemo, thats amazing.  Had the cancer spread anywhere else other than the lymph nodes? My Dad has it on the lower back and pelvis region, but he is so far completely confined to the bed and in too much pain to move.  Did he have radiotherapy?  I have read mixed results about radiotherapy for smal cell.  Any thoughts?  Also was your Dad on etoposide and Carboplatin, these seem to be common chemo drugs from what I have read?  Much appreciated, Kate xox

  • Thank you Colin!  Mum and I are going to try and call one of those numbers tomorrow, as this week we have been returning home too late from the hospital.  They decreased the morphine for a day and a bit and Dad returned but so did the pain, so now that they increased the medication he is pretty much out of it again, which is unfortunate.  I am wondering if it is good to put him through a second round of chemo.  Does the second round get easier or is it worse?

    Cheers, Kate

  • Hi Mal, 

    Thank you for your msg, going to check out the trials on the website now.  If not I shall ask the specialist tomorrow, fingers crossed. 

    Cheers, Kate

  • Hey Sophie, 

    Thanks for your msg, I am just learning my way around this site.  My parents kept it from me so I only found out a week ago, flew home from uni in Canada and I am doing my best to catch up and figure things out.  So I apologise for my not knowing a lot of the terminology etc.  What is CAV?

    My father appears far gone but I am hoping he comes back and it is simply a result of the chemo.  I seem to be doing a lot of care for him at the moment and its a little bewildering, but I suppose this is normal in the week or wks following chemo?  I am wondering how many sessions of chemo did your Dad go through?  Did the cancer spread to other parts of the body or was it localised to the prostate?

    I will let you know if I find out any info on clinical trials I am looking...

    Cheers Kate x