A place for people affected by mesothelioma to support one another, ask questions, and share their experiences.

Effects of Pemetrexed and Cisplatin

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Hello, just wondering how people with Meso have coped with Pemetrexed and Cisplatin? My husband has pleural Mesothelioma (diagnosed May 2016). He started losing weight rapidly and had pain in his left shoulder blade so it was decided to start chemotherapy.  His first cycle was on July 10th. He felt tired and a bit sickly but recovered completely after 10 days. He then had a 20% reduction on his second cycle as the Oncologist thought he was looking tired and not so well. He had the second dose on July 31st and has been so poorly every day! All his joints ache, even his eye sockets. He looks pale and drawn. He is completely wiped out. Even 30 minutes of shopping exhausts him. He was admitted to hospital last night with a raised temperature but his blood tests showed no infection! The doctors assume it’s just the side effects of the chemotherapy. Has anybody else suffered like this? Any help/comments would be appreciated as he is due for Round Three next week!! 

Posted by

Have just seen your post and saw that it hadn’t had a response yet.

I’m not sure I can help with your questions - but my mum has just had her second round of chemotherapy with the same drugs as your husband.

The first round she felt very poorly on day 3and 4. Glands hurt, felt very sick and extremely tired. Then those effects wore off and generally felt a lot better - though eyes started to  hurt towards the end of the 3 weeks. She is now 7 days in on her second course and it has hit her a little harder - though she has had very similar effects as last time - just probably a little more extreme and for a little longer. 

She is due to have a CT scan next week and will be randomised for surgery (no idea if this is a good thing or not - ) if no surgery she will carry on with chemotherapy for another 4 rounds. It is terribly gruelling and made worse by the fact that we don’t really know what if any benefit this will have for her. 

I imagine your husband has had his third cycle of chemotherapy by now. I hope he did ok and remains so.

Thoughts x