A place for people affected by brain tumours or brain cancer to support one another...
Anyone know of any?
Its a May 2019 trial results featured
Hi Kkeith and a second welcome to the online community
I don't have any personal experience with these trials but I noticed that your post hadn't had any replies. I don't know whether you've seen it but you have had a reply to your post on this topic in the brain tumours group. If you haven't seen it clicking here will take you directly to it.
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Ive sent a reply to the mail that was sent.
The big query is having demo strated that the hard to kill gliablastoma cells are killed and affected by DON on mice how do I get the oncologist to prescribe the drug.
Fof anyone interested see the following re DON (6-diazo-5-oxo-L-norleucine)
Cancer-fighting combination targets glioblastoma Date:May 30, 2019Source:Boston CollegeSummary:An international team of researchers combined a calorie-restricted diet high in fat and low in carbohydrates with a tumor-inhibiting antibiotic and found the combination destroys cancer stem cells and mesenchymal cells, the two major cells found in glioblastoma, a fast-moving brain cancer that resists traditional treatment protocols. www.sciencedaily.com/.../190530154220.htm We're not “DON” yet: optimal dosing and prodrug delivery of 6-Diazo-5-oxo-L-norleucine Kathryn M Lemberg, James J Vornov, Rana Rais, Barbara S Slusher Molecular cancer therapeutics 17 (9), 1824-1832, 2018 scholar.google.co.uk/scholar Bioanalysis of 6-diazo-5-oxo-l-norleucine in plasma and brain by ultra-performance liquid chromatography mass spectrometry Jesse Alt, Michelle C Potter, Camilo Rojas, Barbara S Slusher Analytical biochemistry 474, 28-34, 2015 scholar.google.co.uk/scholar Reviving lonidamine and 6-diazo-5-oxo-L-norleucine to be used in combination for metabolic cancer therapy Diana Cervantes-Madrid, Yair Romero, Alfonso Dueñas-González BioMed research international 2015, 2015 scholar.google.co.uk/scholar
Can you make an appointment with your oncologist and ask him whether this treatment is available?
Wishing you all the best
Ive sent him the articals so we shall see.
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