Letrozole side effects

  • 32 replies
  • 481 subscribers
  • 2488 views

I started taking letrozole in the middle of 2022. In the last few months or so, I’ve been feeling phenomenally tired, nauseous and am always cold. I went to see my GP in November and she did some blood tests but they were normal. I’m wondering if it could be letrozole but it seems a long time after starting it for side effects to occur. Has anyine else experienced this?

  • Hi I’ve only been on letrozole 4 months have occasional joint pain ankles mostly during the night when I have to take a painkiller ,during the day I’m fine I take the dogs out for walks with no problems .. have noticed a bit of fatigue is that letrozole.. I don’t know  I’m hoping that’s all ..though reading some of the reply’s may not be .. can but hope ..positive vibes coming everyones way x

  • I’ve been on Letrozole since Nov 22 and I def find the Accord brand the worse .

    I’ve just finished a course of a different brand and started on my new prescription of Accord brand and 4 tablets in I’m feeling exhausted and no appetite so I think you are right in what you say 

  • Hi StellaA 

    Ive been on Letrazole for approx 6 months and am finding lm tired , achy and finding it difficult to get any energy to do anything ,lf l have to do anything l will push myself and manage ok but after two days of this l crash . So frustrating, especially as lm returning to work soon . My oncologist advised me to stick to a certain manufacturer if l found that a certain brand suited me better . Cipla seems to be Okish . I found Accord a bit grim . I’m worried about trying another medication all together as when l started on Letrazole l felt awful , so not keen to have to start all over again with a different medication. 

  • Hi, I have also been on letrozole for 4 months and I have stiff heavy legs and random bone pain also tired all the time. I am 76 and don’t know if it’s my age or if maybe I should change the make as I am using accord. 
    Any advice would be appreciated 

    good luck to everyone on this journey X

  • I’m 70 and been on Letrozole since Nov 22. I’ve just finished 8weeks of the Crescent brand and felt much better on those , now im back on Accord and 5 days in I’m feeling dreadful again . Absolutely washed out , no energy and having to push myself to do everyday chores . My vision is back to being blurred and feeling emotional. It’s really difficult trying to get the same brand every prescription as my chemist , boots gets them delivered to them already made up in sealed blue bags so not dispensed on site . No idea what to do about it as don’t want to be in the position where I can’t get any at all Shrug♀️

  • Thank you that is very interesting as along with the aches and pains I have high blood pressure and anxiety. I am due a review for blood pressure meds so will speak to gp.

    glad that the crescent brand seems to be better for you and hopefully you can continue with that brand.

    take care X

  • Hi Dolly Laker,

    I've been on Letrozole for 7 months and I am having exactly the same side effects as you and no energy at all most of the time! My BC nurse told me that side effects might accumulate over time so I guess that is the case with me. I am also on Abemaciclib for 2 years and I wasn't too sure which causes what. The joys of cancer treatment! Wishing you all the best with your treatment!

    Lana xx

  • Hi Stella,  I too have been on Letrozole for 18 months now along with Abemaciclib, the pain in my legs has got quite bad, some days better than others,my skin is itchy and certain days I feel really fatigued. Even if I sleep OK I'm still tired. I had headaches when I first started them but they went. My oncologist told me to take paracetamol, which don't help.Im still getting stabbing and shooting pains on the site of the mastectomy  and the shoulder and ribs I'm also on Abemaciclib which are givng their own wonderful side effects..mainly diahorrea. 

    Even though it's supposed to go after 2 weeks! Haha...My dose was halved already as the diahorrea was terrible, honestly it's so draining, Sometimes I thik the longer we are on these necessary tablets our bodies are trying to cope with it more. I try hard to live life normally and do things I always have but sometimes I have to give in. Currently I am one big walking side effect!!  Joy  People don't realise even after the operation things never stop.Cancer has certainly changed my life as well as my body..bloody disease! You aren't alone, sometimes that helps knowing others know exactly how you feel. Hope you get some respite from how you're feeling. Big hugs. Jan xx

  • Hi. Sorry to jump in on your reply. Your side effects are exactly the same as mine. I'm on my last amckibeb after almost 25 months on 300mg a day. I chose to take my pension earlier than I should as I couldn't get through a week without exhaustion and pain and bad stomach. I've been in and out of hospital due to infections and