Brain tumours

A place for people affected by brain tumours or brain cancer to support one another, ask questions, and share their experiences.

Trials using the DON antibiotic in combo woth keto diet

Posted by

Anyone know of any?

Its a May 2019 trial results featured

See also



Posted by

Hi , I don’t know if you’ve tried this cancer research link to see if you can find what your looking for.

Best wishes


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Posted by

Thanks KT. It doesnt look like there is anything happening.

From what Ive read it looks like a potentially treatment so I guess I need to find someone eilling to prescrive and iversee it. Fiest stop will be the oncoligist so we shall see.

We are past the chemo stage and its just steroids snd palluative oversight so there is nothing to loose.

For anyone interested here are some relevant articals:

Cancer-fighting combination targets glioblastoma

Date:May 30, 2019Source:Boston CollegeSummary:An international team of researchers combined a calorie-restricted diet high in fat and low in carbohydrates with a tumor-inhibiting antibiotic and found the combination destroys cancer stem cells and mesenchymal cells, the two major cells found in glioblastoma, a fast-moving brain cancer that resists traditional treatment protocols.

We're not “DON” yet: optimal dosing and prodrug delivery of 6-Diazo-5-oxo-L-norleucine

Kathryn M Lemberg, James J Vornov, Rana Rais, Barbara S Slusher

Molecular cancer therapeutics 17 (9), 1824-1832, 2018

Bioanalysis of 6-diazo-5-oxo-l-norleucine in plasma and brain by ultra-performance liquid chromatography mass spectrometry

Jesse Alt, Michelle C Potter, Camilo Rojas, Barbara S Slusher

Analytical biochemistry 474, 28-34, 2015

Reviving lonidamine and 6-diazo-5-oxo-L-norleucine to be used in combination for metabolic cancer therapy

Diana Cervantes-Madrid, Yair Romero, Alfonso Dueñas-González

BioMed research international 2015, 2015

Posted by


Here in the UK it's unlikely you will find an oncologist who will prescribe or be willing to do this on the NHS. 

If you go private you may come across a hopeful doctor willing to help. We are at same stage with my son and he's just on palliative care now so would be interested to see how you get on.