We understand that people with cancer are worried about coronavirus.
Here is the
We will update it regularly.
A support group for anyone affected by leukaemia to come together, share experiences...
Although we make every effort to ensure accuracy, Macmillan Cancer Support cannot accept liability for this information, or for third-party information such as other websites to which we link. If you are concerned about your health you should consult your doctor. Please bear in mind that your question can be read by others - don't post your contact details or any other information that could personally identify you. All answers will be based on information that is correct at the time of posting.
My husband has MDS and PNH. He has an allo SCT in February and is generally doing well, but currently has some issues with chimerism.
His myeloid line (problematic before transplant with transfusion dependency in platelets and HB) now has 100% chimerism (and low normal range blood counts throughout) but the lymphoid line is only 64%. He has had one DLI which has had no effect - another is expected in a few week's time.
Please can you explain to me
a) how the two lines can have such different donor/host mixes?
b) if his lymphoid line remained at 64% donor, what are the implications of this (I know disease relapse is more likely with low T cells). If his lymphoid line was ok pre transplant, would a higher mixed chimerism in this area be more acceptable?
Thanks you your question. It is very common to have a mixed chimerism post transplant especially so early on in the recovery stage, even if the patient is in remission. Each bag of stem cells transplanted has differing amounts of cells and the body uses them at different rates, hence the different mixes in the lines.
The purpose of the DLI is to ensure all the marrow cells come from the donor. Further doses can be given at three monthly intervals. Sometimes several doses of donor lymphocytes are given until the desired effect is reached and the chimerism is increased.
Hope this helps.
Caroline - Macmillan Information Nurse Specialist
Remember you can also speak with the Macmillan Support Line team of experts. Phone free on 0808 808 0000 (7 days a week, 8am-8pm) or by email.
Safe payments by:
We're here to provide physical, financial and emotional support. So whatever cancer throws your way, we're right there with you.
© Macmillan Cancer Support
© Macmillan Cancer Support, registered charity in England and Wales (261017), Scotland (SC039907) and the Isle of Man
(604). Also operating in Northern Ireland. A company limited by guarantee, registered in England and Wales company
number 2400969. Isle of Man company number 4694F. Registered office: 89 Albert Embankment, London SE1 7UQ. VAT no: