Osimertinib and Covid vaccine


i”be been  on Osimertinib (a protein kinase inhibitor) for adenocarcinoma of the lung (nsclc) since May 2020 and doing well.  My bloods are monitored monthly and I’m fit and active.  

I can’t seem to find any answers as to whether it will be safe for me to have a Covid vaccination.  My oncology nurse told me she would run it past the consultant but I’ve heard nothing.  However I’m due to speak to her again next week.  I just wondered whether you had any recent information in this as I understand new info is emerging all the time?

Thank you


  • Hello Liz,

    Many thanks for getting in touch.

    The UK Chemotherapy Board have published this document which discusses the use of various cancer treatments and COVID-19 vaccinations.

    It suggests that patients receiving protein kinase inhibitor treatment should consider the timing of the vaccination in relation to recent blood results but raises no concerns about having the vaccine. (See Table 1)

    It states” It is recommended that all patients receiving systemic anti-cancer therapy (SACT) are considered for CV-19 vaccination.

    It goes on to say that “The Pfizer/BioNTech CV-19 vaccine is not a live vaccine. The Oxford University/AstraZeneca vaccine is a recombinant replication deficient adenovirus which should not be considered as a live vaccine in terms of the risks of SACT co-administration. However, neither vaccine has been trialled in patients receiving SACT.

     However, many cancer patients receiving SACT will fall into the clinically extremely vulnerable category and therefore the overall consensus is that the benefits of the CV-19 vaccine will potentially outweigh the risks.”

    The only specific concern is a history of severe allergic reaction to previous vaccinations.

    I hope this information is helpful and that you get the chance to discuss your vaccination with your oncology nurse next week.

    Take care and best wishes,


    Cancer Information Nurse Specialist